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How to erase memory traces of pain and fear
Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear)....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Applied Science Publishing
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679540/ https://www.ncbi.nlm.nih.gov/pubmed/23602194 http://dx.doi.org/10.1016/j.tins.2013.03.004 |
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author | Sandkühler, Jürgen Lee, Jonathan |
author_facet | Sandkühler, Jürgen Lee, Jonathan |
author_sort | Sandkühler, Jürgen |
collection | PubMed |
description | Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear). Pain and fear may, however, become maladaptive if expressed under inappropriate conditions or at excessive intensities for extended durations. Currently emerging concepts of maladaptive pain and fear suggest that basic neuronal mechanisms of memory formation are relevant for the development of pathological forms of pain and fear. Thus, the processes of erasing memory traces of pain and fear may constitute promising targets for future therapies. |
format | Online Article Text |
id | pubmed-3679540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier Applied Science Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-36795402013-06-12 How to erase memory traces of pain and fear Sandkühler, Jürgen Lee, Jonathan Trends Neurosci Review Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear). Pain and fear may, however, become maladaptive if expressed under inappropriate conditions or at excessive intensities for extended durations. Currently emerging concepts of maladaptive pain and fear suggest that basic neuronal mechanisms of memory formation are relevant for the development of pathological forms of pain and fear. Thus, the processes of erasing memory traces of pain and fear may constitute promising targets for future therapies. Elsevier Applied Science Publishing 2013-06 /pmc/articles/PMC3679540/ /pubmed/23602194 http://dx.doi.org/10.1016/j.tins.2013.03.004 Text en © 2013 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Review Sandkühler, Jürgen Lee, Jonathan How to erase memory traces of pain and fear |
title | How to erase memory traces of pain and fear |
title_full | How to erase memory traces of pain and fear |
title_fullStr | How to erase memory traces of pain and fear |
title_full_unstemmed | How to erase memory traces of pain and fear |
title_short | How to erase memory traces of pain and fear |
title_sort | how to erase memory traces of pain and fear |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679540/ https://www.ncbi.nlm.nih.gov/pubmed/23602194 http://dx.doi.org/10.1016/j.tins.2013.03.004 |
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