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How to erase memory traces of pain and fear

Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear)....

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Detalles Bibliográficos
Autores principales: Sandkühler, Jürgen, Lee, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Applied Science Publishing 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679540/
https://www.ncbi.nlm.nih.gov/pubmed/23602194
http://dx.doi.org/10.1016/j.tins.2013.03.004
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author Sandkühler, Jürgen
Lee, Jonathan
author_facet Sandkühler, Jürgen
Lee, Jonathan
author_sort Sandkühler, Jürgen
collection PubMed
description Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear). Pain and fear may, however, become maladaptive if expressed under inappropriate conditions or at excessive intensities for extended durations. Currently emerging concepts of maladaptive pain and fear suggest that basic neuronal mechanisms of memory formation are relevant for the development of pathological forms of pain and fear. Thus, the processes of erasing memory traces of pain and fear may constitute promising targets for future therapies.
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spelling pubmed-36795402013-06-12 How to erase memory traces of pain and fear Sandkühler, Jürgen Lee, Jonathan Trends Neurosci Review Pain and fear are both aversive experiences that strongly impact on behaviour and well being. They are considered protective when they lead to meaningful, adaptive behaviour such as the avoidance of situations that are potentially dangerous to the integrity of tissue (pain) or the individual (fear). Pain and fear may, however, become maladaptive if expressed under inappropriate conditions or at excessive intensities for extended durations. Currently emerging concepts of maladaptive pain and fear suggest that basic neuronal mechanisms of memory formation are relevant for the development of pathological forms of pain and fear. Thus, the processes of erasing memory traces of pain and fear may constitute promising targets for future therapies. Elsevier Applied Science Publishing 2013-06 /pmc/articles/PMC3679540/ /pubmed/23602194 http://dx.doi.org/10.1016/j.tins.2013.03.004 Text en © 2013 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Review
Sandkühler, Jürgen
Lee, Jonathan
How to erase memory traces of pain and fear
title How to erase memory traces of pain and fear
title_full How to erase memory traces of pain and fear
title_fullStr How to erase memory traces of pain and fear
title_full_unstemmed How to erase memory traces of pain and fear
title_short How to erase memory traces of pain and fear
title_sort how to erase memory traces of pain and fear
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679540/
https://www.ncbi.nlm.nih.gov/pubmed/23602194
http://dx.doi.org/10.1016/j.tins.2013.03.004
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