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No evidence for the development of acute analgesic tolerance during and hyperalgesia after prolonged remifentanil administration in mice
BACKGROUND: Acute opioid tolerance (AOT) and opioid-induced hyperalgesia (OIH) are undesirable effects of opioids that have been reported in both animals and humans. However, the development of AOT and OIH in cases of potent, short-acting μ-opioid receptor agonist remifentanil administration remains...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679751/ https://www.ncbi.nlm.nih.gov/pubmed/23497285 http://dx.doi.org/10.1186/1744-8069-9-11 |