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Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression

BACKGROUND: 10-Hydroxycamptothecin (10-HCPT), isolated from a Chinese tree Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity in vitro and in vivo. It has been shown that HCPT is more active and less toxic than conventional camptothecins a...

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Detalles Bibliográficos
Autores principales:	Fei, Bojian, Chi, Alfred L, Weng, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679846/ https://www.ncbi.nlm.nih.gov/pubmed/23721525 http://dx.doi.org/10.1186/1477-7819-11-120

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