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Incidence, risk factors, and outcomes of Fusobacterium species bacteremia
BACKGROUND: Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679863/ https://www.ncbi.nlm.nih.gov/pubmed/23734900 http://dx.doi.org/10.1186/1471-2334-13-264 |
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author | Afra, Kevin Laupland, Kevin Leal, Jenine Lloyd, Tracie Gregson, Daniel |
author_facet | Afra, Kevin Laupland, Kevin Leal, Jenine Lloyd, Tracie Gregson, Daniel |
author_sort | Afra, Kevin |
collection | PubMed |
description | BACKGROUND: Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical outcomes. METHODS: All cases of Fusobacterium spp. bacteremia detected at a regional microbiology laboratory serving outpatient and acute care for a population of approximately 1.3 million people over 11 years were identified from a computerized database. Clinical data on these cases was extracted from an administrative database and analyzed to determine underlying risk factors for and outcomes of infection. RESULTS: There were 72 incident cases of Fusobacterium spp. bacteremia over the study period (0.55 cases/100,000 population per annum). F. nucleatum was the most frequent species (61%), followed by F. necrophorum (25%). F. necrophorum bacteremia occurred in a younger population without underlying comorbidities and was not associated with mortality. F. nucleatum bacteremia was found in an older population and was associated with underlying malignancy or receiving dialysis. Death occurred in approximately 10% of F. nucleatum cases but causality was not established in this study. CONCLUSIONS: Fusobacterium spp. bacteremia in our community is uncommon and occurs in approximately 5.5 cases per million population per annum. F. necrophorum occurred in an otherwise young healthy population and was not associated with any mortality. F. nucleatum was found primarily in older patients with chronic medical conditions and was associated with a mortality of approximately 10%. Bacteremias from other Fusobacterium spp. were rare. |
format | Online Article Text |
id | pubmed-3679863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36798632013-06-13 Incidence, risk factors, and outcomes of Fusobacterium species bacteremia Afra, Kevin Laupland, Kevin Leal, Jenine Lloyd, Tracie Gregson, Daniel BMC Infect Dis Research Article BACKGROUND: Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical outcomes. METHODS: All cases of Fusobacterium spp. bacteremia detected at a regional microbiology laboratory serving outpatient and acute care for a population of approximately 1.3 million people over 11 years were identified from a computerized database. Clinical data on these cases was extracted from an administrative database and analyzed to determine underlying risk factors for and outcomes of infection. RESULTS: There were 72 incident cases of Fusobacterium spp. bacteremia over the study period (0.55 cases/100,000 population per annum). F. nucleatum was the most frequent species (61%), followed by F. necrophorum (25%). F. necrophorum bacteremia occurred in a younger population without underlying comorbidities and was not associated with mortality. F. nucleatum bacteremia was found in an older population and was associated with underlying malignancy or receiving dialysis. Death occurred in approximately 10% of F. nucleatum cases but causality was not established in this study. CONCLUSIONS: Fusobacterium spp. bacteremia in our community is uncommon and occurs in approximately 5.5 cases per million population per annum. F. necrophorum occurred in an otherwise young healthy population and was not associated with any mortality. F. nucleatum was found primarily in older patients with chronic medical conditions and was associated with a mortality of approximately 10%. Bacteremias from other Fusobacterium spp. were rare. BioMed Central 2013-06-05 /pmc/articles/PMC3679863/ /pubmed/23734900 http://dx.doi.org/10.1186/1471-2334-13-264 Text en Copyright © 2013 Afra et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Afra, Kevin Laupland, Kevin Leal, Jenine Lloyd, Tracie Gregson, Daniel Incidence, risk factors, and outcomes of Fusobacterium species bacteremia |
title | Incidence, risk factors, and outcomes of Fusobacterium species bacteremia |
title_full | Incidence, risk factors, and outcomes of Fusobacterium species bacteremia |
title_fullStr | Incidence, risk factors, and outcomes of Fusobacterium species bacteremia |
title_full_unstemmed | Incidence, risk factors, and outcomes of Fusobacterium species bacteremia |
title_short | Incidence, risk factors, and outcomes of Fusobacterium species bacteremia |
title_sort | incidence, risk factors, and outcomes of fusobacterium species bacteremia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679863/ https://www.ncbi.nlm.nih.gov/pubmed/23734900 http://dx.doi.org/10.1186/1471-2334-13-264 |
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