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Incidence, risk factors, and outcomes of Fusobacterium species bacteremia

BACKGROUND: Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection a...

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Autores principales: Afra, Kevin, Laupland, Kevin, Leal, Jenine, Lloyd, Tracie, Gregson, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679863/
https://www.ncbi.nlm.nih.gov/pubmed/23734900
http://dx.doi.org/10.1186/1471-2334-13-264
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author Afra, Kevin
Laupland, Kevin
Leal, Jenine
Lloyd, Tracie
Gregson, Daniel
author_facet Afra, Kevin
Laupland, Kevin
Leal, Jenine
Lloyd, Tracie
Gregson, Daniel
author_sort Afra, Kevin
collection PubMed
description BACKGROUND: Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical outcomes. METHODS: All cases of Fusobacterium spp. bacteremia detected at a regional microbiology laboratory serving outpatient and acute care for a population of approximately 1.3 million people over 11 years were identified from a computerized database. Clinical data on these cases was extracted from an administrative database and analyzed to determine underlying risk factors for and outcomes of infection. RESULTS: There were 72 incident cases of Fusobacterium spp. bacteremia over the study period (0.55 cases/100,000 population per annum). F. nucleatum was the most frequent species (61%), followed by F. necrophorum (25%). F. necrophorum bacteremia occurred in a younger population without underlying comorbidities and was not associated with mortality. F. nucleatum bacteremia was found in an older population and was associated with underlying malignancy or receiving dialysis. Death occurred in approximately 10% of F. nucleatum cases but causality was not established in this study. CONCLUSIONS: Fusobacterium spp. bacteremia in our community is uncommon and occurs in approximately 5.5 cases per million population per annum. F. necrophorum occurred in an otherwise young healthy population and was not associated with any mortality. F. nucleatum was found primarily in older patients with chronic medical conditions and was associated with a mortality of approximately 10%. Bacteremias from other Fusobacterium spp. were rare.
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spelling pubmed-36798632013-06-13 Incidence, risk factors, and outcomes of Fusobacterium species bacteremia Afra, Kevin Laupland, Kevin Leal, Jenine Lloyd, Tracie Gregson, Daniel BMC Infect Dis Research Article BACKGROUND: Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical outcomes. METHODS: All cases of Fusobacterium spp. bacteremia detected at a regional microbiology laboratory serving outpatient and acute care for a population of approximately 1.3 million people over 11 years were identified from a computerized database. Clinical data on these cases was extracted from an administrative database and analyzed to determine underlying risk factors for and outcomes of infection. RESULTS: There were 72 incident cases of Fusobacterium spp. bacteremia over the study period (0.55 cases/100,000 population per annum). F. nucleatum was the most frequent species (61%), followed by F. necrophorum (25%). F. necrophorum bacteremia occurred in a younger population without underlying comorbidities and was not associated with mortality. F. nucleatum bacteremia was found in an older population and was associated with underlying malignancy or receiving dialysis. Death occurred in approximately 10% of F. nucleatum cases but causality was not established in this study. CONCLUSIONS: Fusobacterium spp. bacteremia in our community is uncommon and occurs in approximately 5.5 cases per million population per annum. F. necrophorum occurred in an otherwise young healthy population and was not associated with any mortality. F. nucleatum was found primarily in older patients with chronic medical conditions and was associated with a mortality of approximately 10%. Bacteremias from other Fusobacterium spp. were rare. BioMed Central 2013-06-05 /pmc/articles/PMC3679863/ /pubmed/23734900 http://dx.doi.org/10.1186/1471-2334-13-264 Text en Copyright © 2013 Afra et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Afra, Kevin
Laupland, Kevin
Leal, Jenine
Lloyd, Tracie
Gregson, Daniel
Incidence, risk factors, and outcomes of Fusobacterium species bacteremia
title Incidence, risk factors, and outcomes of Fusobacterium species bacteremia
title_full Incidence, risk factors, and outcomes of Fusobacterium species bacteremia
title_fullStr Incidence, risk factors, and outcomes of Fusobacterium species bacteremia
title_full_unstemmed Incidence, risk factors, and outcomes of Fusobacterium species bacteremia
title_short Incidence, risk factors, and outcomes of Fusobacterium species bacteremia
title_sort incidence, risk factors, and outcomes of fusobacterium species bacteremia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679863/
https://www.ncbi.nlm.nih.gov/pubmed/23734900
http://dx.doi.org/10.1186/1471-2334-13-264
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