Cargando…

Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome

BACKGROUND: The impact of the Mediterranean diet (MedDiet) on high-density lipoprotein (HDL) kinetics has not been studied to date. The objective of this study was therefore to investigate the effect of the MedDiet in the absence of changes in body weight on apolipoprotein (apo) A-I kinetic in men w...

Descripción completa

Detalles Bibliográficos
Autores principales: Richard, Caroline, Couture, Patrick, Desroches, Sophie, Lichtenstein, Alice H, Lamarche, Benoît
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679868/
https://www.ncbi.nlm.nih.gov/pubmed/24499022
http://dx.doi.org/10.1186/1475-2891-12-76
_version_ 1782273034642522112
author Richard, Caroline
Couture, Patrick
Desroches, Sophie
Lichtenstein, Alice H
Lamarche, Benoît
author_facet Richard, Caroline
Couture, Patrick
Desroches, Sophie
Lichtenstein, Alice H
Lamarche, Benoît
author_sort Richard, Caroline
collection PubMed
description BACKGROUND: The impact of the Mediterranean diet (MedDiet) on high-density lipoprotein (HDL) kinetics has not been studied to date. The objective of this study was therefore to investigate the effect of the MedDiet in the absence of changes in body weight on apolipoprotein (apo) A-I kinetic in men with metabolic syndrome (MetS). METHODS: Twenty-six men with MetS (NCEP-ATP III) were recruited from the general community. In this fixed sequence study, participants’ diet was first standardized to a control diet reflecting current averages in macronutrient intake in North American men, with all foods and beverages provided under isoenergetic conditions for 5 weeks. Participants were then fed an isoenergetic MedDiet over a subsequent period of 5 weeks to maintain their weight constant. During the last week of each diet, participants received a single bolus dose of [5,5,5-(2)H(3)] (L)-leucine and fasting blood samples were collected at predetermined time points. ApoA-I kinetic was determined by multicompartmental modeling using isotopic enrichment data over time. Data were analyses using MIXED models. RESULTS: The response of HDL-cholesterol (C) to MedDiet was heterogeneous, such that there was no mean change compared with the control diet. Plasma apoA-I concentration (−3.9%) and pool size (−5.3%, both P < 0.05) were significantly lower after MedDiet and apoA-I production rate tended to be reduced (−5.7%, P = 0.07) with no change in apoA-I fractional catabolic rate (FCR, -1.6%, P = 0.64). Participants among whom HDL-C concentrations were increased with MedDiet (responders: mean ∆HDL-C: +9.9 ± 3.2%, N = 11) showed significantly greater reductions in apoA-I FCR and in apoB and very-low-density lipoprotein-triglycerides (VLDL-TG) concentrations (all P < 0.04) than those among whom HDL-C levels were reduced after the MedDiet (non-responders: mean ∆HDL-C: -12.0 ± 3.9%, N = 8). Correlation analysis revealed that only variations in apoA-I FCR (r = -0.48, P = 0.01) and in plasma VLDL-TG (r = −0.45, P = 0.03) concentrations were correlated with the individual HDL-C response to the MedDiet. CONCLUSIONS: Data from this controlled feeding study suggest that the heterogeneous response of HDL-C to MedDiet, in the absence of important weight loss, is primarily related to individual variations in apoA-I FCR and in plasma VLDL-TG concentrations. TRIAL REGISTRATION: ClinicalTrial.gov registration number: NCT00988650
format Online
Article
Text
id pubmed-3679868
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-36798682013-06-13 Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome Richard, Caroline Couture, Patrick Desroches, Sophie Lichtenstein, Alice H Lamarche, Benoît Nutr J Research BACKGROUND: The impact of the Mediterranean diet (MedDiet) on high-density lipoprotein (HDL) kinetics has not been studied to date. The objective of this study was therefore to investigate the effect of the MedDiet in the absence of changes in body weight on apolipoprotein (apo) A-I kinetic in men with metabolic syndrome (MetS). METHODS: Twenty-six men with MetS (NCEP-ATP III) were recruited from the general community. In this fixed sequence study, participants’ diet was first standardized to a control diet reflecting current averages in macronutrient intake in North American men, with all foods and beverages provided under isoenergetic conditions for 5 weeks. Participants were then fed an isoenergetic MedDiet over a subsequent period of 5 weeks to maintain their weight constant. During the last week of each diet, participants received a single bolus dose of [5,5,5-(2)H(3)] (L)-leucine and fasting blood samples were collected at predetermined time points. ApoA-I kinetic was determined by multicompartmental modeling using isotopic enrichment data over time. Data were analyses using MIXED models. RESULTS: The response of HDL-cholesterol (C) to MedDiet was heterogeneous, such that there was no mean change compared with the control diet. Plasma apoA-I concentration (−3.9%) and pool size (−5.3%, both P < 0.05) were significantly lower after MedDiet and apoA-I production rate tended to be reduced (−5.7%, P = 0.07) with no change in apoA-I fractional catabolic rate (FCR, -1.6%, P = 0.64). Participants among whom HDL-C concentrations were increased with MedDiet (responders: mean ∆HDL-C: +9.9 ± 3.2%, N = 11) showed significantly greater reductions in apoA-I FCR and in apoB and very-low-density lipoprotein-triglycerides (VLDL-TG) concentrations (all P < 0.04) than those among whom HDL-C levels were reduced after the MedDiet (non-responders: mean ∆HDL-C: -12.0 ± 3.9%, N = 8). Correlation analysis revealed that only variations in apoA-I FCR (r = -0.48, P = 0.01) and in plasma VLDL-TG (r = −0.45, P = 0.03) concentrations were correlated with the individual HDL-C response to the MedDiet. CONCLUSIONS: Data from this controlled feeding study suggest that the heterogeneous response of HDL-C to MedDiet, in the absence of important weight loss, is primarily related to individual variations in apoA-I FCR and in plasma VLDL-TG concentrations. TRIAL REGISTRATION: ClinicalTrial.gov registration number: NCT00988650 BioMed Central 2013-06-07 /pmc/articles/PMC3679868/ /pubmed/24499022 http://dx.doi.org/10.1186/1475-2891-12-76 Text en Copyright © 2013 Richard et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Richard, Caroline
Couture, Patrick
Desroches, Sophie
Lichtenstein, Alice H
Lamarche, Benoît
Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome
title Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome
title_full Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome
title_fullStr Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome
title_full_unstemmed Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome
title_short Effect of an isoenergetic traditional Mediterranean diet on apolipoprotein A-I kinetic in men with metabolic syndrome
title_sort effect of an isoenergetic traditional mediterranean diet on apolipoprotein a-i kinetic in men with metabolic syndrome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679868/
https://www.ncbi.nlm.nih.gov/pubmed/24499022
http://dx.doi.org/10.1186/1475-2891-12-76
work_keys_str_mv AT richardcaroline effectofanisoenergetictraditionalmediterraneandietonapolipoproteinaikineticinmenwithmetabolicsyndrome
AT couturepatrick effectofanisoenergetictraditionalmediterraneandietonapolipoproteinaikineticinmenwithmetabolicsyndrome
AT desrochessophie effectofanisoenergetictraditionalmediterraneandietonapolipoproteinaikineticinmenwithmetabolicsyndrome
AT lichtensteinaliceh effectofanisoenergetictraditionalmediterraneandietonapolipoproteinaikineticinmenwithmetabolicsyndrome
AT lamarchebenoit effectofanisoenergetictraditionalmediterraneandietonapolipoproteinaikineticinmenwithmetabolicsyndrome