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Gene expression profiling reveals distinct features of various porcine adipose tissues
BACKGROUND: The excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adipose deposition, we used pig as a model, and measured the gene expression profil...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679871/ https://www.ncbi.nlm.nih.gov/pubmed/23705929 http://dx.doi.org/10.1186/1476-511X-12-75 |
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author | Zhou, Chaowei Zhang, Jie Ma, Jideng Jiang, Anan Tang, Guoqing Mai, Miaomiao Zhu, Li Bai, Lin Li, Mingzhou Li, Xuewei |
author_facet | Zhou, Chaowei Zhang, Jie Ma, Jideng Jiang, Anan Tang, Guoqing Mai, Miaomiao Zhu, Li Bai, Lin Li, Mingzhou Li, Xuewei |
author_sort | Zhou, Chaowei |
collection | PubMed |
description | BACKGROUND: The excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adipose deposition, we used pig as a model, and measured the gene expression profiling of six variant adipose tissues in male and females from three pig breeds which display distinct fat level. RESULTS: We identified various differential expressed genes among breeds, tissues and between sexes, and further used a clustering method to identify sets of functionally co-expression genes linked to different obesity-related phenotypes. Our results reveal that the subcutaneous adipose tissues mainly modulate metabolic indicators, nonetheless, the visceral adipose tissues as well as the intermuscular adipose tissue were mainly associated with the impaired inflammatory and immune response. CONCLUSIONS: The present study provided the evidence of gene expression profiling that the subcutaneous adipose tissues are mainly affected the metabolism process, whereas the visceral and intermuscular adipose tissues should been term as the metabolic risk factors of obesity. |
format | Online Article Text |
id | pubmed-3679871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36798712013-06-13 Gene expression profiling reveals distinct features of various porcine adipose tissues Zhou, Chaowei Zhang, Jie Ma, Jideng Jiang, Anan Tang, Guoqing Mai, Miaomiao Zhu, Li Bai, Lin Li, Mingzhou Li, Xuewei Lipids Health Dis Research BACKGROUND: The excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adipose deposition, we used pig as a model, and measured the gene expression profiling of six variant adipose tissues in male and females from three pig breeds which display distinct fat level. RESULTS: We identified various differential expressed genes among breeds, tissues and between sexes, and further used a clustering method to identify sets of functionally co-expression genes linked to different obesity-related phenotypes. Our results reveal that the subcutaneous adipose tissues mainly modulate metabolic indicators, nonetheless, the visceral adipose tissues as well as the intermuscular adipose tissue were mainly associated with the impaired inflammatory and immune response. CONCLUSIONS: The present study provided the evidence of gene expression profiling that the subcutaneous adipose tissues are mainly affected the metabolism process, whereas the visceral and intermuscular adipose tissues should been term as the metabolic risk factors of obesity. BioMed Central 2013-05-24 /pmc/articles/PMC3679871/ /pubmed/23705929 http://dx.doi.org/10.1186/1476-511X-12-75 Text en Copyright © 2013 Zhou et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Zhou, Chaowei Zhang, Jie Ma, Jideng Jiang, Anan Tang, Guoqing Mai, Miaomiao Zhu, Li Bai, Lin Li, Mingzhou Li, Xuewei Gene expression profiling reveals distinct features of various porcine adipose tissues |
title | Gene expression profiling reveals distinct features of various porcine adipose tissues |
title_full | Gene expression profiling reveals distinct features of various porcine adipose tissues |
title_fullStr | Gene expression profiling reveals distinct features of various porcine adipose tissues |
title_full_unstemmed | Gene expression profiling reveals distinct features of various porcine adipose tissues |
title_short | Gene expression profiling reveals distinct features of various porcine adipose tissues |
title_sort | gene expression profiling reveals distinct features of various porcine adipose tissues |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679871/ https://www.ncbi.nlm.nih.gov/pubmed/23705929 http://dx.doi.org/10.1186/1476-511X-12-75 |
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