Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage

BACKGROUND: A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed. FINDINGS: Analysis of the data revealed the different growth kinetics for the different isolate...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Karen Caiyun, Kam, Yiu-Wing, Lin, Raymond Tzer Pin, Ng, Mary Mah-Lee, Ng, Lisa FP, Chu, Justin Jang Hann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679931/
https://www.ncbi.nlm.nih.gov/pubmed/23721429
http://dx.doi.org/10.1186/1743-422X-10-169
Descripción
Sumario:BACKGROUND: A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed. FINDINGS: Analysis of the data revealed the different growth kinetics for the different isolates. Deep genome sequencing analysis further revealed specific amino acid mutations in the viral nsP1, nsP3, nsP4, E1 and E2 proteins in the different isolates. Despite the difference in viral genomic profiles, the virus-induced ultrastructural changes within infected cells remained highly conserved among the different chikungunya virus isolates. CONCLUSIONS: These findings provide insights into the genomic and replication profiles of the re-emerging chikungunya virus isolates of the ECSA lineage.

Ejemplares similares