Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage

BACKGROUND: A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed. FINDINGS: Analysis of the data revealed the different growth kinetics for the different isolate...

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Autores principales: Chen, Karen Caiyun, Kam, Yiu-Wing, Lin, Raymond Tzer Pin, Ng, Mary Mah-Lee, Ng, Lisa FP, Chu, Justin Jang Hann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679931/
https://www.ncbi.nlm.nih.gov/pubmed/23721429
http://dx.doi.org/10.1186/1743-422X-10-169
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author Chen, Karen Caiyun
Kam, Yiu-Wing
Lin, Raymond Tzer Pin
Ng, Mary Mah-Lee
Ng, Lisa FP
Chu, Justin Jang Hann
author_facet Chen, Karen Caiyun
Kam, Yiu-Wing
Lin, Raymond Tzer Pin
Ng, Mary Mah-Lee
Ng, Lisa FP
Chu, Justin Jang Hann
author_sort Chen, Karen Caiyun
collection PubMed
description BACKGROUND: A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed. FINDINGS: Analysis of the data revealed the different growth kinetics for the different isolates. Deep genome sequencing analysis further revealed specific amino acid mutations in the viral nsP1, nsP3, nsP4, E1 and E2 proteins in the different isolates. Despite the difference in viral genomic profiles, the virus-induced ultrastructural changes within infected cells remained highly conserved among the different chikungunya virus isolates. CONCLUSIONS: These findings provide insights into the genomic and replication profiles of the re-emerging chikungunya virus isolates of the ECSA lineage.
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spelling pubmed-36799312013-06-13 Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage Chen, Karen Caiyun Kam, Yiu-Wing Lin, Raymond Tzer Pin Ng, Mary Mah-Lee Ng, Lisa FP Chu, Justin Jang Hann Virol J Short Report BACKGROUND: A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed. FINDINGS: Analysis of the data revealed the different growth kinetics for the different isolates. Deep genome sequencing analysis further revealed specific amino acid mutations in the viral nsP1, nsP3, nsP4, E1 and E2 proteins in the different isolates. Despite the difference in viral genomic profiles, the virus-induced ultrastructural changes within infected cells remained highly conserved among the different chikungunya virus isolates. CONCLUSIONS: These findings provide insights into the genomic and replication profiles of the re-emerging chikungunya virus isolates of the ECSA lineage. BioMed Central 2013-05-30 /pmc/articles/PMC3679931/ /pubmed/23721429 http://dx.doi.org/10.1186/1743-422X-10-169 Text en Copyright © 2013 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Chen, Karen Caiyun
Kam, Yiu-Wing
Lin, Raymond Tzer Pin
Ng, Mary Mah-Lee
Ng, Lisa FP
Chu, Justin Jang Hann
Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
title Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
title_full Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
title_fullStr Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
title_full_unstemmed Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
title_short Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage
title_sort comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the east, central and south african (ecsa) lineage
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679931/
https://www.ncbi.nlm.nih.gov/pubmed/23721429
http://dx.doi.org/10.1186/1743-422X-10-169
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