UpSETing chromatin during non-coding RNA production

The packaging of eukaryotic DNA into nucleosomal arrays permits cells to tightly regulate and fine-tune gene expression. The ordered disassembly and reassembly of these nucleosomes allows RNA polymerase II (RNAPII) conditional access to the underlying DNA sequences. Disruption of nucleosome reassemb...

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Detalles Bibliográficos
Autores principales: Venkatesh, Swaminathan, Workman, Jerry L, Smolle, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680234/
https://www.ncbi.nlm.nih.gov/pubmed/23738864
http://dx.doi.org/10.1186/1756-8935-6-16
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author Venkatesh, Swaminathan
Workman, Jerry L
Smolle, Michaela
author_facet Venkatesh, Swaminathan
Workman, Jerry L
Smolle, Michaela
author_sort Venkatesh, Swaminathan
collection PubMed
description The packaging of eukaryotic DNA into nucleosomal arrays permits cells to tightly regulate and fine-tune gene expression. The ordered disassembly and reassembly of these nucleosomes allows RNA polymerase II (RNAPII) conditional access to the underlying DNA sequences. Disruption of nucleosome reassembly following RNAPII passage results in spurious transcription initiation events, leading to the production of non-coding RNA (ncRNA). We review the molecular mechanisms involved in the suppression of these cryptic initiation events and discuss the role played by ncRNAs in regulating gene expression.
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spelling pubmed-36802342013-06-13 UpSETing chromatin during non-coding RNA production Venkatesh, Swaminathan Workman, Jerry L Smolle, Michaela Epigenetics Chromatin Review The packaging of eukaryotic DNA into nucleosomal arrays permits cells to tightly regulate and fine-tune gene expression. The ordered disassembly and reassembly of these nucleosomes allows RNA polymerase II (RNAPII) conditional access to the underlying DNA sequences. Disruption of nucleosome reassembly following RNAPII passage results in spurious transcription initiation events, leading to the production of non-coding RNA (ncRNA). We review the molecular mechanisms involved in the suppression of these cryptic initiation events and discuss the role played by ncRNAs in regulating gene expression. BioMed Central 2013-06-05 /pmc/articles/PMC3680234/ /pubmed/23738864 http://dx.doi.org/10.1186/1756-8935-6-16 Text en Copyright © 2013 Venkatesh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Venkatesh, Swaminathan
Workman, Jerry L
Smolle, Michaela
UpSETing chromatin during non-coding RNA production
title UpSETing chromatin during non-coding RNA production
title_full UpSETing chromatin during non-coding RNA production
title_fullStr UpSETing chromatin during non-coding RNA production
title_full_unstemmed UpSETing chromatin during non-coding RNA production
title_short UpSETing chromatin during non-coding RNA production
title_sort upseting chromatin during non-coding rna production
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680234/
https://www.ncbi.nlm.nih.gov/pubmed/23738864
http://dx.doi.org/10.1186/1756-8935-6-16
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