Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement

BACKGROUND: FK506 is an important immunosuppressant, which can be produced by Streptomyces tsukubaensis. However, the production capacity of the strain is very low. Hereby, a computational guided engineering approach was proposed in order to improve the intracellular precursor and cofactor availabil...

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Detalles Bibliográficos
Autores principales: Huang, Di, Li, Shanshan, Xia, Menglei, Wen, Jianping, Jia, Xiaoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680238/
https://www.ncbi.nlm.nih.gov/pubmed/23705993
http://dx.doi.org/10.1186/1475-2859-12-52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680238/
https://www.ncbi.nlm.nih.gov/pubmed/23705993
http://dx.doi.org/10.1186/1475-2859-12-52

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