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Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement
BACKGROUND: FK506 is an important immunosuppressant, which can be produced by Streptomyces tsukubaensis. However, the production capacity of the strain is very low. Hereby, a computational guided engineering approach was proposed in order to improve the intracellular precursor and cofactor availabil...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680238/ https://www.ncbi.nlm.nih.gov/pubmed/23705993 http://dx.doi.org/10.1186/1475-2859-12-52 |