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Urine Bisphenol-A Level in Relation to Obesity and Overweight in School-Age Children

Bisphenol-A (BPA) is a potential endocrine disruptor impacting metabolic processes and increasing the risk of obesity. To determine whether urine BPA level is associated with overweight/obesity in school-age children, we examined 1,326 students in grades 4–12 from three schools (one elementary, one...

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Autores principales: Li, De-Kun, Miao, Maohua, Zhou, ZhiJun, Wu, Chunhua, Shi, Huijing, Liu, Xiaoqin, Wang, Siqi, Yuan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680397/
https://www.ncbi.nlm.nih.gov/pubmed/23776476
http://dx.doi.org/10.1371/journal.pone.0065399
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author Li, De-Kun
Miao, Maohua
Zhou, ZhiJun
Wu, Chunhua
Shi, Huijing
Liu, Xiaoqin
Wang, Siqi
Yuan, Wei
author_facet Li, De-Kun
Miao, Maohua
Zhou, ZhiJun
Wu, Chunhua
Shi, Huijing
Liu, Xiaoqin
Wang, Siqi
Yuan, Wei
author_sort Li, De-Kun
collection PubMed
description Bisphenol-A (BPA) is a potential endocrine disruptor impacting metabolic processes and increasing the risk of obesity. To determine whether urine BPA level is associated with overweight/obesity in school-age children, we examined 1,326 students in grades 4–12 from three schools (one elementary, one middle, and one high school) in Shanghai. More than 98% of eligible students participated. Total urine BPA concentration was measured and anthropometric measures were taken by trained research staff. Information on risk factors for childhood obesity was collected for potential confounders. Age- and gender-specific weight greater than 90(th) percentile of the underlying population was the outcome measure. After adjustment for potential confounders, a higher urine BPA level (≥2 µg/L), at the level corresponding to the median urine BPA level in the U.S. population, was associated with more than two-fold increased risk of having weight >90(th) percentile among girls aged 9–12 (adjusted odds ratio (aOR) = 2.32, 95% confidence interval: 1.15–4.65). The association showed a dose-response relationship with increasing urine BPA level associated with further increased risk of overweight (p = 0.006 for trend test). Other anthropometric measures of obesity showed similar results. The same association was not observed among boys. This gender difference of BPA effect was consistent with findings from experimental studies and previous epidemiological studies. Our study suggests that BPA could be a potential new environmental obesogen. Widespread exposure to BPA in the human population may also be contributing to the worldwide obesity epidemic.
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spelling pubmed-36803972013-06-17 Urine Bisphenol-A Level in Relation to Obesity and Overweight in School-Age Children Li, De-Kun Miao, Maohua Zhou, ZhiJun Wu, Chunhua Shi, Huijing Liu, Xiaoqin Wang, Siqi Yuan, Wei PLoS One Research Article Bisphenol-A (BPA) is a potential endocrine disruptor impacting metabolic processes and increasing the risk of obesity. To determine whether urine BPA level is associated with overweight/obesity in school-age children, we examined 1,326 students in grades 4–12 from three schools (one elementary, one middle, and one high school) in Shanghai. More than 98% of eligible students participated. Total urine BPA concentration was measured and anthropometric measures were taken by trained research staff. Information on risk factors for childhood obesity was collected for potential confounders. Age- and gender-specific weight greater than 90(th) percentile of the underlying population was the outcome measure. After adjustment for potential confounders, a higher urine BPA level (≥2 µg/L), at the level corresponding to the median urine BPA level in the U.S. population, was associated with more than two-fold increased risk of having weight >90(th) percentile among girls aged 9–12 (adjusted odds ratio (aOR) = 2.32, 95% confidence interval: 1.15–4.65). The association showed a dose-response relationship with increasing urine BPA level associated with further increased risk of overweight (p = 0.006 for trend test). Other anthropometric measures of obesity showed similar results. The same association was not observed among boys. This gender difference of BPA effect was consistent with findings from experimental studies and previous epidemiological studies. Our study suggests that BPA could be a potential new environmental obesogen. Widespread exposure to BPA in the human population may also be contributing to the worldwide obesity epidemic. Public Library of Science 2013-06-12 /pmc/articles/PMC3680397/ /pubmed/23776476 http://dx.doi.org/10.1371/journal.pone.0065399 Text en © 2013 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Li, De-Kun
Miao, Maohua
Zhou, ZhiJun
Wu, Chunhua
Shi, Huijing
Liu, Xiaoqin
Wang, Siqi
Yuan, Wei
Urine Bisphenol-A Level in Relation to Obesity and Overweight in School-Age Children
title Urine Bisphenol-A Level in Relation to Obesity and Overweight in School-Age Children
title_full Urine Bisphenol-A Level in Relation to Obesity and Overweight in School-Age Children
title_fullStr Urine Bisphenol-A Level in Relation to Obesity and Overweight in School-Age Children
title_full_unstemmed Urine Bisphenol-A Level in Relation to Obesity and Overweight in School-Age Children
title_short Urine Bisphenol-A Level in Relation to Obesity and Overweight in School-Age Children
title_sort urine bisphenol-a level in relation to obesity and overweight in school-age children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680397/
https://www.ncbi.nlm.nih.gov/pubmed/23776476
http://dx.doi.org/10.1371/journal.pone.0065399
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