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Ligand Induced Conformational Changes of the Human Serotonin Transporter Revealed by Molecular Dynamics Simulations

The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter. It has been shown from accessibility experiments that cocaine mainly induces an outward-facing conformation, while the non-competitive inhibitor ibo...

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Detalles Bibliográficos
Autores principales:	Koldsø, Heidi, Autzen, Henriette Elisabeth, Grouleff, Julie, Schiøtt, Birgit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680404/ https://www.ncbi.nlm.nih.gov/pubmed/23776432 http://dx.doi.org/10.1371/journal.pone.0063635

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