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Engineered External Guide Sequences Are Highly Effective in Inhibiting Gene Expression and Replication of Hepatitis B Virus in Cultured Cells

External guide sequences (EGSs) are RNA molecules that consist of a sequence complementary to a target mRNA and recruit intracellular ribonuclease P (RNase P), a tRNA processing enzyme, for specific degradation of the target mRNA. We have previously used an in vitro selection procedure to generate E...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhigang, Vu, Gia-Phong, Gong, Hao, Xia, Chuan, Chen, Yuan-Chuan, Liu, Fenyong, Wu, Jianguo, Lu, Sangwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680410/ https://www.ncbi.nlm.nih.gov/pubmed/23776459 http://dx.doi.org/10.1371/journal.pone.0065268

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