Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

The EVI1 (ecotropic viral integration site 1) gene at 3q26 codes for a transcriptional regulator with an essential role in haematopoiesis. Overexpression of EVI1 in acute myeloid leukaemia (AML) is frequently associated with 3q26 rearrangements and confers extremely poor prognosis. EVI1 mediates tra...

Descripción completa

Detalles Bibliográficos
Autores principales: White, Daniel J., Unwin, Richard D., Bindels, Eric, Pierce, Andrew, Teng, Hsiang-Ying, Muter, Joanne, Greystoke, Brigit, Somerville, Tim D., Griffiths, John, Lovell, Simon, Somervaille, Tim C. P., Delwel, Ruud, Whetton, Anthony D., Meyer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680417/
https://www.ncbi.nlm.nih.gov/pubmed/23776681
http://dx.doi.org/10.1371/journal.pone.0066510

Ejemplares similares

Ejemplares similares