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The Impact of Age, Sex and Socioeconomic Deprivation on Outcomes in a Colorectal Cancer Screening Programme
BACKGROUND: Population-based colorectal cancer screening has been shown to reduce cancer specific mortality and is used across the UK. Despite evidence that older age, male sex and deprivation are associated with an increased incidence of colorectal cancer, uptake of bowel cancer screening varies ac...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680425/ https://www.ncbi.nlm.nih.gov/pubmed/23776606 http://dx.doi.org/10.1371/journal.pone.0066063 |
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author | Mansouri, David McMillan, Donald C. Grant, Yasmin Crighton, Emilia M. Horgan, Paul G. |
author_facet | Mansouri, David McMillan, Donald C. Grant, Yasmin Crighton, Emilia M. Horgan, Paul G. |
author_sort | Mansouri, David |
collection | PubMed |
description | BACKGROUND: Population-based colorectal cancer screening has been shown to reduce cancer specific mortality and is used across the UK. Despite evidence that older age, male sex and deprivation are associated with an increased incidence of colorectal cancer, uptake of bowel cancer screening varies across demographic groups. The aim of this study was to assess the impact of age, sex and deprivation on outcomes throughout the screening process. METHODS: A prospectively maintained database, encompassing the first screening round of a faecal occult blood test screening programme in a single geographical area, was analysed. RESULTS: Overall, 395 096 individuals were invited to screening, 204 139 (52%) participated and 6 079 (3%) tested positive. Of the positive tests, 4 625 (76%) attended for colonoscopy and cancer was detected in 396 individuals (9%). Lower uptake of screening was associated with younger age, male sex and deprivation (all p<0.001). Only deprivation was associated with failure to proceed to colonoscopy following a positive test (p<0.001). Despite higher positivity rates in those that were more deprived (p<0.001), the likelihood of detecting cancer in those attending for colonoscopy was lower (8% most deprived vs 10% least deprived, p = 0.003). CONCLUSION: Individuals who are deprived are less likely to participate in screening, less likely to undergo colonoscopy and less likely to have cancer identified as a result of a positive test. Therefore, this study suggests that strategies aimed at improving participation of deprived individuals in colorectal cancer screening should be directed at all stages of the screening process and not just uptake of the test. |
format | Online Article Text |
id | pubmed-3680425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36804252013-06-17 The Impact of Age, Sex and Socioeconomic Deprivation on Outcomes in a Colorectal Cancer Screening Programme Mansouri, David McMillan, Donald C. Grant, Yasmin Crighton, Emilia M. Horgan, Paul G. PLoS One Research Article BACKGROUND: Population-based colorectal cancer screening has been shown to reduce cancer specific mortality and is used across the UK. Despite evidence that older age, male sex and deprivation are associated with an increased incidence of colorectal cancer, uptake of bowel cancer screening varies across demographic groups. The aim of this study was to assess the impact of age, sex and deprivation on outcomes throughout the screening process. METHODS: A prospectively maintained database, encompassing the first screening round of a faecal occult blood test screening programme in a single geographical area, was analysed. RESULTS: Overall, 395 096 individuals were invited to screening, 204 139 (52%) participated and 6 079 (3%) tested positive. Of the positive tests, 4 625 (76%) attended for colonoscopy and cancer was detected in 396 individuals (9%). Lower uptake of screening was associated with younger age, male sex and deprivation (all p<0.001). Only deprivation was associated with failure to proceed to colonoscopy following a positive test (p<0.001). Despite higher positivity rates in those that were more deprived (p<0.001), the likelihood of detecting cancer in those attending for colonoscopy was lower (8% most deprived vs 10% least deprived, p = 0.003). CONCLUSION: Individuals who are deprived are less likely to participate in screening, less likely to undergo colonoscopy and less likely to have cancer identified as a result of a positive test. Therefore, this study suggests that strategies aimed at improving participation of deprived individuals in colorectal cancer screening should be directed at all stages of the screening process and not just uptake of the test. Public Library of Science 2013-06-12 /pmc/articles/PMC3680425/ /pubmed/23776606 http://dx.doi.org/10.1371/journal.pone.0066063 Text en © 2013 Mansouri et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Mansouri, David McMillan, Donald C. Grant, Yasmin Crighton, Emilia M. Horgan, Paul G. The Impact of Age, Sex and Socioeconomic Deprivation on Outcomes in a Colorectal Cancer Screening Programme |
title | The Impact of Age, Sex and Socioeconomic Deprivation on Outcomes in a Colorectal Cancer Screening Programme |
title_full | The Impact of Age, Sex and Socioeconomic Deprivation on Outcomes in a Colorectal Cancer Screening Programme |
title_fullStr | The Impact of Age, Sex and Socioeconomic Deprivation on Outcomes in a Colorectal Cancer Screening Programme |
title_full_unstemmed | The Impact of Age, Sex and Socioeconomic Deprivation on Outcomes in a Colorectal Cancer Screening Programme |
title_short | The Impact of Age, Sex and Socioeconomic Deprivation on Outcomes in a Colorectal Cancer Screening Programme |
title_sort | impact of age, sex and socioeconomic deprivation on outcomes in a colorectal cancer screening programme |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680425/ https://www.ncbi.nlm.nih.gov/pubmed/23776606 http://dx.doi.org/10.1371/journal.pone.0066063 |
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