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Variables Involved in the Discordance between HbA1c and Fructosamine: The Glycation Gap Revisited
AIMS: Glycation gap (GG) is defined as the difference between the measured level of HbA1c and the level that would be predicted from its regression on the fructosamine level. The aims of the study were: 1) To determine the reproducibility and consistency of GC; 2) To discover factors related to GG v...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680426/ https://www.ncbi.nlm.nih.gov/pubmed/23776693 http://dx.doi.org/10.1371/journal.pone.0066696 |
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author | Zafon, Carles Ciudin, Andreea Valladares, Silvia Mesa, Jordi Simó, Rafael |
author_facet | Zafon, Carles Ciudin, Andreea Valladares, Silvia Mesa, Jordi Simó, Rafael |
author_sort | Zafon, Carles |
collection | PubMed |
description | AIMS: Glycation gap (GG) is defined as the difference between the measured level of HbA1c and the level that would be predicted from its regression on the fructosamine level. The aims of the study were: 1) To determine the reproducibility and consistency of GC; 2) To discover factors related to GG value. Given that metformin might increase glucose transport through the erythrocyte membrane, this treatment was also considered in the analyses of the results. METHODS: GG was calculated in two blood samples separated 30.6 (SD 7.3) weeks, obtained in 508 type 2 diabetic patients. The following variables were considered: HbA1c, fructosamine, glucose, creatinine, hematological parameters and treatment with metformin. Multivariate and logistic regression analyses were performed to explore the variables independently related to CG. RESULTS: GG was reproducible and consistent over time. Creatinine, mean corpuscular hemoglobin concentration (MCHC), and glycemia (inverse relationship); and HbA1c and treatment with metformin (direct relationship) were independently related to GG. Patients treated with metformin showed higher HbA1c values, despite similar fructosamine concentrations, than patients not treated with the drug. CONCLUSIONS: GG is independently related to serum levels of creatinine, MCHC and treatment with metformin. The spurious effect of metformin on Hb glycation could have serious clinical implications and should be considered when interpreting the results of clinical trials. |
format | Online Article Text |
id | pubmed-3680426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36804262013-06-17 Variables Involved in the Discordance between HbA1c and Fructosamine: The Glycation Gap Revisited Zafon, Carles Ciudin, Andreea Valladares, Silvia Mesa, Jordi Simó, Rafael PLoS One Research Article AIMS: Glycation gap (GG) is defined as the difference between the measured level of HbA1c and the level that would be predicted from its regression on the fructosamine level. The aims of the study were: 1) To determine the reproducibility and consistency of GC; 2) To discover factors related to GG value. Given that metformin might increase glucose transport through the erythrocyte membrane, this treatment was also considered in the analyses of the results. METHODS: GG was calculated in two blood samples separated 30.6 (SD 7.3) weeks, obtained in 508 type 2 diabetic patients. The following variables were considered: HbA1c, fructosamine, glucose, creatinine, hematological parameters and treatment with metformin. Multivariate and logistic regression analyses were performed to explore the variables independently related to CG. RESULTS: GG was reproducible and consistent over time. Creatinine, mean corpuscular hemoglobin concentration (MCHC), and glycemia (inverse relationship); and HbA1c and treatment with metformin (direct relationship) were independently related to GG. Patients treated with metformin showed higher HbA1c values, despite similar fructosamine concentrations, than patients not treated with the drug. CONCLUSIONS: GG is independently related to serum levels of creatinine, MCHC and treatment with metformin. The spurious effect of metformin on Hb glycation could have serious clinical implications and should be considered when interpreting the results of clinical trials. Public Library of Science 2013-06-12 /pmc/articles/PMC3680426/ /pubmed/23776693 http://dx.doi.org/10.1371/journal.pone.0066696 Text en © 2013 Zafon et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zafon, Carles Ciudin, Andreea Valladares, Silvia Mesa, Jordi Simó, Rafael Variables Involved in the Discordance between HbA1c and Fructosamine: The Glycation Gap Revisited |
title | Variables Involved in the Discordance between HbA1c and Fructosamine: The Glycation Gap Revisited |
title_full | Variables Involved in the Discordance between HbA1c and Fructosamine: The Glycation Gap Revisited |
title_fullStr | Variables Involved in the Discordance between HbA1c and Fructosamine: The Glycation Gap Revisited |
title_full_unstemmed | Variables Involved in the Discordance between HbA1c and Fructosamine: The Glycation Gap Revisited |
title_short | Variables Involved in the Discordance between HbA1c and Fructosamine: The Glycation Gap Revisited |
title_sort | variables involved in the discordance between hba1c and fructosamine: the glycation gap revisited |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680426/ https://www.ncbi.nlm.nih.gov/pubmed/23776693 http://dx.doi.org/10.1371/journal.pone.0066696 |
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