Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined. Characteristics of motor neurons affected in FA...

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Detalles Bibliográficos
Autores principales: Morfini, Gerardo A., Bosco, Daryl A., Brown, Hannah, Gatto, Rodolfo, Kaminska, Agnieszka, Song, Yuyu, Molla, Linda, Baker, Lisa, Marangoni, M. Natalia, Berth, Sarah, Tavassoli, Ehsan, Bagnato, Carolina, Tiwari, Ashutosh, Hayward, Lawrence J., Pigino, Gustavo F., Watterson, D. Martin, Huang, Chun-Fang, Banker, Gary, Brown, Robert H., Brady, Scott T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680447/
https://www.ncbi.nlm.nih.gov/pubmed/23776455
http://dx.doi.org/10.1371/journal.pone.0065235

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