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A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation
INTRODUCTION: This study describes a pivotal clinical trial of a new minimally invasive mesotherapy technique for facial rejuvenation. METHODS: The authors utilized two formulations: formulation A with hyaluronic acid, vitamins, amino acids, minerals, coenzymes, and antioxidant substances; formulati...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680640/ https://www.ncbi.nlm.nih.gov/pubmed/23888258 http://dx.doi.org/10.1007/s13555-012-0018-2 |
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author | Savoia, Antonella Landi, Simone Baldi, Alfonso |
author_facet | Savoia, Antonella Landi, Simone Baldi, Alfonso |
author_sort | Savoia, Antonella |
collection | PubMed |
description | INTRODUCTION: This study describes a pivotal clinical trial of a new minimally invasive mesotherapy technique for facial rejuvenation. METHODS: The authors utilized two formulations: formulation A with hyaluronic acid, vitamins, amino acids, minerals, coenzymes, and antioxidant substances; formulation B with hyaluronic acid and idebenone. Fifty participants were enrolled in the study and divided in two groups. Group 1 (50–65 years) treated with formulation A. Group 2 (35–50 years) treated with formulation B. The groups underwent four sessions of mesotherapy involving multiple injections. Treatment was conducted at 15 day intervals. All participants had pre- and posttreatment photographs. Punch biopsies were taken from randomly selected participants, baseline and after 6 weeks, and stained for interleukin (IL)-6, IL-1β, matrix metalloproteinase (MMP)-1, and collagen 1. Clinical evaluation was based on the Global Aesthetic Scale (GAIS) and on the Wrinkle Severity Rating Scale (WSRS). RESULTS: The results produced were statistically analyzed and resulted in a significant and long-lasting effect on facial rejuvenation. Evaluation of photographs at 0, 1, and 2 months revealed significant clinical improvement: brightness, texture, and firmness of the skin. The analysis of the GAIS and WSRS scores in the two groups demonstrated statistically significant results after 2 months. The biopsies taken from randomly selected participants at baseline and after 3 months showed a decrease in IL-1β, IL-6, and MMP1, and an increase in collagen 1. CONCLUSION: The new minimally invasive mesotherapy technique described can improve the clinical appearance of the skin in different age groups. |
format | Online Article Text |
id | pubmed-3680640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-36806402013-06-13 A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation Savoia, Antonella Landi, Simone Baldi, Alfonso Dermatol Ther (Heidelb) Original Research INTRODUCTION: This study describes a pivotal clinical trial of a new minimally invasive mesotherapy technique for facial rejuvenation. METHODS: The authors utilized two formulations: formulation A with hyaluronic acid, vitamins, amino acids, minerals, coenzymes, and antioxidant substances; formulation B with hyaluronic acid and idebenone. Fifty participants were enrolled in the study and divided in two groups. Group 1 (50–65 years) treated with formulation A. Group 2 (35–50 years) treated with formulation B. The groups underwent four sessions of mesotherapy involving multiple injections. Treatment was conducted at 15 day intervals. All participants had pre- and posttreatment photographs. Punch biopsies were taken from randomly selected participants, baseline and after 6 weeks, and stained for interleukin (IL)-6, IL-1β, matrix metalloproteinase (MMP)-1, and collagen 1. Clinical evaluation was based on the Global Aesthetic Scale (GAIS) and on the Wrinkle Severity Rating Scale (WSRS). RESULTS: The results produced were statistically analyzed and resulted in a significant and long-lasting effect on facial rejuvenation. Evaluation of photographs at 0, 1, and 2 months revealed significant clinical improvement: brightness, texture, and firmness of the skin. The analysis of the GAIS and WSRS scores in the two groups demonstrated statistically significant results after 2 months. The biopsies taken from randomly selected participants at baseline and after 3 months showed a decrease in IL-1β, IL-6, and MMP1, and an increase in collagen 1. CONCLUSION: The new minimally invasive mesotherapy technique described can improve the clinical appearance of the skin in different age groups. Springer Healthcare 2013-01-08 /pmc/articles/PMC3680640/ /pubmed/23888258 http://dx.doi.org/10.1007/s13555-012-0018-2 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Research Savoia, Antonella Landi, Simone Baldi, Alfonso A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation |
title | A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation |
title_full | A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation |
title_fullStr | A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation |
title_full_unstemmed | A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation |
title_short | A New Minimally Invasive Mesotherapy Technique for Facial Rejuvenation |
title_sort | new minimally invasive mesotherapy technique for facial rejuvenation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680640/ https://www.ncbi.nlm.nih.gov/pubmed/23888258 http://dx.doi.org/10.1007/s13555-012-0018-2 |
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