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Cortical organization of inhibition-related functions and modulation by psychopathology

Individual differences in inhibition-related functions have been implicated as risk factors for a broad range of psychopathology, including anxiety and depression. Delineating neural mechanisms of distinct inhibition-related functions may clarify their role in the development and maintenance of psyc...

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Autores principales: Warren, Stacie L., Crocker, Laura D., Spielberg, Jeffery M., Engels, Anna S., Banich, Marie T., Sutton, Bradley P., Miller, Gregory A., Heller, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680711/
https://www.ncbi.nlm.nih.gov/pubmed/23781192
http://dx.doi.org/10.3389/fnhum.2013.00271
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author Warren, Stacie L.
Crocker, Laura D.
Spielberg, Jeffery M.
Engels, Anna S.
Banich, Marie T.
Sutton, Bradley P.
Miller, Gregory A.
Heller, Wendy
author_facet Warren, Stacie L.
Crocker, Laura D.
Spielberg, Jeffery M.
Engels, Anna S.
Banich, Marie T.
Sutton, Bradley P.
Miller, Gregory A.
Heller, Wendy
author_sort Warren, Stacie L.
collection PubMed
description Individual differences in inhibition-related functions have been implicated as risk factors for a broad range of psychopathology, including anxiety and depression. Delineating neural mechanisms of distinct inhibition-related functions may clarify their role in the development and maintenance of psychopathology. The present study tested the hypothesis that activity in common and distinct brain regions would be associated with an ecologically sensitive, self-report measure of inhibition and a laboratory performance measure of prepotent response inhibition. Results indicated that sub-regions of DLPFC distinguished measures of inhibition, whereas left inferior frontal gyrus and bilateral inferior parietal cortex were associated with both types of inhibition. Additionally, co-occurring anxiety and depression modulated neural activity in select brain regions associated with response inhibition. Results imply that specific combinations of anxiety and depression dimensions are associated with failure to implement top-down attentional control as reflected in inefficient recruitment of posterior DLPFC and increased activation in regions associated with threat (MTG) and worry (BA10). Present findings elucidate possible neural mechanisms of interference that could help explain executive control deficits in psychopathology.
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spelling pubmed-36807112013-06-18 Cortical organization of inhibition-related functions and modulation by psychopathology Warren, Stacie L. Crocker, Laura D. Spielberg, Jeffery M. Engels, Anna S. Banich, Marie T. Sutton, Bradley P. Miller, Gregory A. Heller, Wendy Front Hum Neurosci Neuroscience Individual differences in inhibition-related functions have been implicated as risk factors for a broad range of psychopathology, including anxiety and depression. Delineating neural mechanisms of distinct inhibition-related functions may clarify their role in the development and maintenance of psychopathology. The present study tested the hypothesis that activity in common and distinct brain regions would be associated with an ecologically sensitive, self-report measure of inhibition and a laboratory performance measure of prepotent response inhibition. Results indicated that sub-regions of DLPFC distinguished measures of inhibition, whereas left inferior frontal gyrus and bilateral inferior parietal cortex were associated with both types of inhibition. Additionally, co-occurring anxiety and depression modulated neural activity in select brain regions associated with response inhibition. Results imply that specific combinations of anxiety and depression dimensions are associated with failure to implement top-down attentional control as reflected in inefficient recruitment of posterior DLPFC and increased activation in regions associated with threat (MTG) and worry (BA10). Present findings elucidate possible neural mechanisms of interference that could help explain executive control deficits in psychopathology. Frontiers Media S.A. 2013-06-13 /pmc/articles/PMC3680711/ /pubmed/23781192 http://dx.doi.org/10.3389/fnhum.2013.00271 Text en Copyright © 2013 Warren, Crocker, Spielberg, Engels, Banich, Sutton, Miller and Heller. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Warren, Stacie L.
Crocker, Laura D.
Spielberg, Jeffery M.
Engels, Anna S.
Banich, Marie T.
Sutton, Bradley P.
Miller, Gregory A.
Heller, Wendy
Cortical organization of inhibition-related functions and modulation by psychopathology
title Cortical organization of inhibition-related functions and modulation by psychopathology
title_full Cortical organization of inhibition-related functions and modulation by psychopathology
title_fullStr Cortical organization of inhibition-related functions and modulation by psychopathology
title_full_unstemmed Cortical organization of inhibition-related functions and modulation by psychopathology
title_short Cortical organization of inhibition-related functions and modulation by psychopathology
title_sort cortical organization of inhibition-related functions and modulation by psychopathology
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680711/
https://www.ncbi.nlm.nih.gov/pubmed/23781192
http://dx.doi.org/10.3389/fnhum.2013.00271
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