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Pif1 family helicases suppress genome instability at G-quadruplex motifs

The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. We show that exceptionally potent G-quadruplex unwinding is conserved amongst Pif1 helicases. Moreover, Pif1 helicases from organisms separated by >3...

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Detalles Bibliográficos
Autores principales:	Paeschke, Katrin, Bochman, Matthew L., Garcia, P. Daniela, Cejka, Petr, Friedman, Katherine L., Kowalczykowski, Stephen C., Zakian, Virginia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680789/ https://www.ncbi.nlm.nih.gov/pubmed/23657261 http://dx.doi.org/10.1038/nature12149

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