Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer

INTRODUCTION: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is diagnosed in approximately 15% of all human breast cancer (BrCa) patients. Currently, no targeted therapies exist for this subtype of BrCa and prognosis remains poor. Our laboratory has previously id...

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Detalles Bibliográficos
Autores principales: Bennett, Christina N, Tomlinson, Christine C, Michalowski, Aleksandra M, Chu, Isabel M, Luger, Dror, Mittereder, Lara R, Aprelikova, Olga, Shou, James, Piwinica-Worms, Helen, Caplen, Natasha J, Hollingshead, Melinda G, Green, Jeffrey E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680937/
https://www.ncbi.nlm.nih.gov/pubmed/22812567
http://dx.doi.org/10.1186/bcr3230

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