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Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study

BACKGROUND: Most patients presenting with advanced ovarian cancer (AOC) eventually relapse. Symptom palliation, maintenance of quality of life (QoL) and prolongation of life are primary therapeutic goals. METHODS: Sixty-six UK oncologists completed an online survey about AOC management. Two hundred...

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Autores principales: Jenkins, V, Catt, S, Banerjee, S, Gourley, C, Montes, A, Solis-Trapala, I, Monson, K, Fallowfield, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681025/
https://www.ncbi.nlm.nih.gov/pubmed/23652312
http://dx.doi.org/10.1038/bjc.2013.223
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author Jenkins, V
Catt, S
Banerjee, S
Gourley, C
Montes, A
Solis-Trapala, I
Monson, K
Fallowfield, L
author_facet Jenkins, V
Catt, S
Banerjee, S
Gourley, C
Montes, A
Solis-Trapala, I
Monson, K
Fallowfield, L
author_sort Jenkins, V
collection PubMed
description BACKGROUND: Most patients presenting with advanced ovarian cancer (AOC) eventually relapse. Symptom palliation, maintenance of quality of life (QoL) and prolongation of life are primary therapeutic goals. METHODS: Sixty-six UK oncologists completed an online survey about AOC management. Two hundred and two patients were interviewed about care, treatment experiences and expectations. RESULTS: Prior to diagnosis, 34% (69 out of 202) of women had ⩾3 symptoms associated with AOC. Twenty-one per cent (43 out of 202) thought poor symptom recognition by general practitioners (GPs) delayed diagnosis. Amelioration of side effects experienced was variable, for example, only 54% (68 out of 127) distressed by alopecia had received sufficient information about it. Clinicians were asked ‘What minimum gain in progression-free survival (PFS) would make you feel it worthwhile to offer maintenance therapy?' 48% (24 out of 50) indicated 5–6 months, but 52% (26 out of 50) believed patients would find PFS of 3–4 months acceptable. When patients were presented with hypothetical scenarios, 33% (52 out of 160) would require 1–2 months extra life, 6% (10 out of 160) 3–4 months, 31% (49 out of 160) 5–6 months, and 31% (49 out of 160) ⩾7 months. However, 86% (173 out of 202) would accept treatment that improved QoL without prolongation of life. When asked what was most important, 33% (67 out of 201) said QoL, 9% (19 out of 201) length of life and 57% (115 out of 201) said both were equally important. CONCLUSION: Clinicians' and patients' experiences, expectations and priorities about OC management may differ.
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spelling pubmed-36810252014-06-11 Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study Jenkins, V Catt, S Banerjee, S Gourley, C Montes, A Solis-Trapala, I Monson, K Fallowfield, L Br J Cancer Clinical Study BACKGROUND: Most patients presenting with advanced ovarian cancer (AOC) eventually relapse. Symptom palliation, maintenance of quality of life (QoL) and prolongation of life are primary therapeutic goals. METHODS: Sixty-six UK oncologists completed an online survey about AOC management. Two hundred and two patients were interviewed about care, treatment experiences and expectations. RESULTS: Prior to diagnosis, 34% (69 out of 202) of women had ⩾3 symptoms associated with AOC. Twenty-one per cent (43 out of 202) thought poor symptom recognition by general practitioners (GPs) delayed diagnosis. Amelioration of side effects experienced was variable, for example, only 54% (68 out of 127) distressed by alopecia had received sufficient information about it. Clinicians were asked ‘What minimum gain in progression-free survival (PFS) would make you feel it worthwhile to offer maintenance therapy?' 48% (24 out of 50) indicated 5–6 months, but 52% (26 out of 50) believed patients would find PFS of 3–4 months acceptable. When patients were presented with hypothetical scenarios, 33% (52 out of 160) would require 1–2 months extra life, 6% (10 out of 160) 3–4 months, 31% (49 out of 160) 5–6 months, and 31% (49 out of 160) ⩾7 months. However, 86% (173 out of 202) would accept treatment that improved QoL without prolongation of life. When asked what was most important, 33% (67 out of 201) said QoL, 9% (19 out of 201) length of life and 57% (115 out of 201) said both were equally important. CONCLUSION: Clinicians' and patients' experiences, expectations and priorities about OC management may differ. Nature Publishing Group 2013-06-11 2013-05-07 /pmc/articles/PMC3681025/ /pubmed/23652312 http://dx.doi.org/10.1038/bjc.2013.223 Text en Copyright © 2013 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Clinical Study
Jenkins, V
Catt, S
Banerjee, S
Gourley, C
Montes, A
Solis-Trapala, I
Monson, K
Fallowfield, L
Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study
title Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study
title_full Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study
title_fullStr Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study
title_full_unstemmed Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study
title_short Patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the UK: results from the ADVOCATE study
title_sort patients' and oncologists' views on the treatment and care of advanced ovarian cancer in the uk: results from the advocate study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681025/
https://www.ncbi.nlm.nih.gov/pubmed/23652312
http://dx.doi.org/10.1038/bjc.2013.223
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