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Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo

BACKGROUND: The tyrosine kinase receptor HER4 is a member of the epidermal growth factor receptor (EGFR) family. It plays diverse roles in cancer development and cancer progression and can both exert oncogenic and tumour-suppressive activities. Alternatively spliced isoforms of HER4 are critical to...

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Detalles Bibliográficos
Autores principales:	Nielsen, T O, Sorensen, S, Dagnæs-Hansen, F, Kjems, J, Sorensen, B S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681029/ https://www.ncbi.nlm.nih.gov/pubmed/23695025 http://dx.doi.org/10.1038/bjc.2013.247

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