Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population

Nowadays diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD). Recent studies have demonstrated that the myosin, heavy chain 9, non-muscle (MYH9) gene is associated with ESRD in African Americans. In this study, we tested the hypothesis that a common single nucleotide...

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Autores principales: Hsieh, Chang-Hsun, Hung, Yi-Jen, Pei, Dee, Kuo, Shi-Wen, Lin, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681160/
https://www.ncbi.nlm.nih.gov/pubmed/23776349
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author Hsieh, Chang-Hsun
Hung, Yi-Jen
Pei, Dee
Kuo, Shi-Wen
Lin, Eugene
author_facet Hsieh, Chang-Hsun
Hung, Yi-Jen
Pei, Dee
Kuo, Shi-Wen
Lin, Eugene
author_sort Hsieh, Chang-Hsun
collection PubMed
description Nowadays diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD). Recent studies have demonstrated that the myosin, heavy chain 9, non-muscle (MYH9) gene is associated with ESRD in African Americans. In this study, we tested the hypothesis that a common single nucleotide polymorphism rs16996677 in the MYH9 gene may contribute to the etiology of DN in type 2 diabetes (T2D) in a Taiwanese population with T2D. There were 180 T2D patients diagnosed with DN and 178 age- and sex-similar T2D without DN controls. Single locus analyses showed no significant main effects of MYH9 rs16996677 on the risk of DN in T2D. The results suggest that the rs16996677 SNP in MYH9 may not contribute to the risk of DN in T2D in Taiwanese T2D patients.
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spelling pubmed-36811602013-06-17 Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population Hsieh, Chang-Hsun Hung, Yi-Jen Pei, Dee Kuo, Shi-Wen Lin, Eugene Appl Clin Genet Original Research Nowadays diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD). Recent studies have demonstrated that the myosin, heavy chain 9, non-muscle (MYH9) gene is associated with ESRD in African Americans. In this study, we tested the hypothesis that a common single nucleotide polymorphism rs16996677 in the MYH9 gene may contribute to the etiology of DN in type 2 diabetes (T2D) in a Taiwanese population with T2D. There were 180 T2D patients diagnosed with DN and 178 age- and sex-similar T2D without DN controls. Single locus analyses showed no significant main effects of MYH9 rs16996677 on the risk of DN in T2D. The results suggest that the rs16996677 SNP in MYH9 may not contribute to the risk of DN in T2D in Taiwanese T2D patients. Dove Medical Press 2010-03-16 /pmc/articles/PMC3681160/ /pubmed/23776349 Text en © 2010 Hsieh et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Hsieh, Chang-Hsun
Hung, Yi-Jen
Pei, Dee
Kuo, Shi-Wen
Lin, Eugene
Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population
title Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population
title_full Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population
title_fullStr Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population
title_full_unstemmed Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population
title_short Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population
title_sort pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (myh9) gene and type 2 diabetic nephropathy in a taiwanese population
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681160/
https://www.ncbi.nlm.nih.gov/pubmed/23776349
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