Cargando…

Cellular Mechanisms of Multiple Myeloma Bone Disease

Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a n...

Descripción completa

Detalles Bibliográficos
Autores principales: Oranger, Angela, Carbone, Claudia, Izzo, Maddalena, Grano, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681224/
https://www.ncbi.nlm.nih.gov/pubmed/23818912
http://dx.doi.org/10.1155/2013/289458
_version_ 1782273226153394176
author Oranger, Angela
Carbone, Claudia
Izzo, Maddalena
Grano, Maria
author_facet Oranger, Angela
Carbone, Claudia
Izzo, Maddalena
Grano, Maria
author_sort Oranger, Angela
collection PubMed
description Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival. MM osteolytic bone lesions arise from the altered bone remodeling due to both increased osteoclast activation and decreased osteoblast differentiation. A dysregulated production of numerous cytokines that can contribute to the uncoupling of bone cell activity is well documented in the bone marrow microenvironment of MM patients. These molecules are produced not only by malignant plasma cells, that directly contribute to MM bone disease, but also by bone, immune, and stromal cells interacting with each other in the bone microenvironment. This review focuses on the current knowledge of MM bone disease biology, with particular regard on the role of bone and immune cells in producing cytokines critical for malignant plasma cell proliferation as well as in osteolysis development. Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden.
format Online
Article
Text
id pubmed-3681224
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36812242013-07-01 Cellular Mechanisms of Multiple Myeloma Bone Disease Oranger, Angela Carbone, Claudia Izzo, Maddalena Grano, Maria Clin Dev Immunol Review Article Multiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival. MM osteolytic bone lesions arise from the altered bone remodeling due to both increased osteoclast activation and decreased osteoblast differentiation. A dysregulated production of numerous cytokines that can contribute to the uncoupling of bone cell activity is well documented in the bone marrow microenvironment of MM patients. These molecules are produced not only by malignant plasma cells, that directly contribute to MM bone disease, but also by bone, immune, and stromal cells interacting with each other in the bone microenvironment. This review focuses on the current knowledge of MM bone disease biology, with particular regard on the role of bone and immune cells in producing cytokines critical for malignant plasma cell proliferation as well as in osteolysis development. Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden. Hindawi Publishing Corporation 2013 2013-05-29 /pmc/articles/PMC3681224/ /pubmed/23818912 http://dx.doi.org/10.1155/2013/289458 Text en Copyright © 2013 Angela Oranger et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oranger, Angela
Carbone, Claudia
Izzo, Maddalena
Grano, Maria
Cellular Mechanisms of Multiple Myeloma Bone Disease
title Cellular Mechanisms of Multiple Myeloma Bone Disease
title_full Cellular Mechanisms of Multiple Myeloma Bone Disease
title_fullStr Cellular Mechanisms of Multiple Myeloma Bone Disease
title_full_unstemmed Cellular Mechanisms of Multiple Myeloma Bone Disease
title_short Cellular Mechanisms of Multiple Myeloma Bone Disease
title_sort cellular mechanisms of multiple myeloma bone disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681224/
https://www.ncbi.nlm.nih.gov/pubmed/23818912
http://dx.doi.org/10.1155/2013/289458
work_keys_str_mv AT orangerangela cellularmechanismsofmultiplemyelomabonedisease
AT carboneclaudia cellularmechanismsofmultiplemyelomabonedisease
AT izzomaddalena cellularmechanismsofmultiplemyelomabonedisease
AT granomaria cellularmechanismsofmultiplemyelomabonedisease