Cargando…
Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth
Preterm birth is defined as any delivery before 37 complete weeks of gestation. It is a universal challenge in the field of obstetrics owing to its high rate of mortality, long-term morbidity, associated human suffering and economic burden. In the United States, about 12.18% deliveries in 2009 were...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681286/ https://www.ncbi.nlm.nih.gov/pubmed/23818902 http://dx.doi.org/10.1155/2013/302952 |
_version_ | 1782273236447264768 |
---|---|
author | Vyas, Vibhuti Ashby, Charles R. Reznik, Sandra E. |
author_facet | Vyas, Vibhuti Ashby, Charles R. Reznik, Sandra E. |
author_sort | Vyas, Vibhuti |
collection | PubMed |
description | Preterm birth is defined as any delivery before 37 complete weeks of gestation. It is a universal challenge in the field of obstetrics owing to its high rate of mortality, long-term morbidity, associated human suffering and economic burden. In the United States, about 12.18% deliveries in 2009 were preterm, producing an exorbitant cost of $5.8 billion. Infection-associated premature rupture of membranes (PROM) accounts for 40% of extremely preterm births (<28 weeks of gestation). Major research efforts are directed towards improving the understanding of the pathophysiology of preterm birth and ways to prevent or at least postpone delivery. Endothelin-1 (ET-1) is a potent vasoconstrictor that plays a significant role in infection-triggered preterm birth. Its involvement in a number of pathological mechanisms and its elevation in preterm delivered amniotic fluid samples implicate it in preterm birth. Sphingosine kinase (SphK) is a ubiquitous enzyme responsible for the production of sphingosine-1-phosphate (S1P). S1P acts as second messenger in a number of cell proliferation and survival pathways. SphK is found to play a key role in ET-1 mediated myometrial contraction. This review highlights SphK as a prospective target with great potential to prevent preterm birth. |
format | Online Article Text |
id | pubmed-3681286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36812862013-07-01 Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth Vyas, Vibhuti Ashby, Charles R. Reznik, Sandra E. Obstet Gynecol Int Review Article Preterm birth is defined as any delivery before 37 complete weeks of gestation. It is a universal challenge in the field of obstetrics owing to its high rate of mortality, long-term morbidity, associated human suffering and economic burden. In the United States, about 12.18% deliveries in 2009 were preterm, producing an exorbitant cost of $5.8 billion. Infection-associated premature rupture of membranes (PROM) accounts for 40% of extremely preterm births (<28 weeks of gestation). Major research efforts are directed towards improving the understanding of the pathophysiology of preterm birth and ways to prevent or at least postpone delivery. Endothelin-1 (ET-1) is a potent vasoconstrictor that plays a significant role in infection-triggered preterm birth. Its involvement in a number of pathological mechanisms and its elevation in preterm delivered amniotic fluid samples implicate it in preterm birth. Sphingosine kinase (SphK) is a ubiquitous enzyme responsible for the production of sphingosine-1-phosphate (S1P). S1P acts as second messenger in a number of cell proliferation and survival pathways. SphK is found to play a key role in ET-1 mediated myometrial contraction. This review highlights SphK as a prospective target with great potential to prevent preterm birth. Hindawi Publishing Corporation 2013 2013-05-26 /pmc/articles/PMC3681286/ /pubmed/23818902 http://dx.doi.org/10.1155/2013/302952 Text en Copyright © 2013 Vibhuti Vyas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Vyas, Vibhuti Ashby, Charles R. Reznik, Sandra E. Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth |
title | Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth |
title_full | Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth |
title_fullStr | Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth |
title_full_unstemmed | Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth |
title_short | Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth |
title_sort | sphingosine kinase: a novel putative target for the prevention of infection-triggered preterm birth |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681286/ https://www.ncbi.nlm.nih.gov/pubmed/23818902 http://dx.doi.org/10.1155/2013/302952 |
work_keys_str_mv | AT vyasvibhuti sphingosinekinaseanovelputativetargetforthepreventionofinfectiontriggeredpretermbirth AT ashbycharlesr sphingosinekinaseanovelputativetargetforthepreventionofinfectiontriggeredpretermbirth AT rezniksandrae sphingosinekinaseanovelputativetargetforthepreventionofinfectiontriggeredpretermbirth |