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Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth

Preterm birth is defined as any delivery before 37 complete weeks of gestation. It is a universal challenge in the field of obstetrics owing to its high rate of mortality, long-term morbidity, associated human suffering and economic burden. In the United States, about 12.18% deliveries in 2009 were...

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Autores principales: Vyas, Vibhuti, Ashby, Charles R., Reznik, Sandra E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681286/
https://www.ncbi.nlm.nih.gov/pubmed/23818902
http://dx.doi.org/10.1155/2013/302952
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author Vyas, Vibhuti
Ashby, Charles R.
Reznik, Sandra E.
author_facet Vyas, Vibhuti
Ashby, Charles R.
Reznik, Sandra E.
author_sort Vyas, Vibhuti
collection PubMed
description Preterm birth is defined as any delivery before 37 complete weeks of gestation. It is a universal challenge in the field of obstetrics owing to its high rate of mortality, long-term morbidity, associated human suffering and economic burden. In the United States, about 12.18% deliveries in 2009 were preterm, producing an exorbitant cost of $5.8 billion. Infection-associated premature rupture of membranes (PROM) accounts for 40% of extremely preterm births (<28 weeks of gestation). Major research efforts are directed towards improving the understanding of the pathophysiology of preterm birth and ways to prevent or at least postpone delivery. Endothelin-1 (ET-1) is a potent vasoconstrictor that plays a significant role in infection-triggered preterm birth. Its involvement in a number of pathological mechanisms and its elevation in preterm delivered amniotic fluid samples implicate it in preterm birth. Sphingosine kinase (SphK) is a ubiquitous enzyme responsible for the production of sphingosine-1-phosphate (S1P). S1P acts as second messenger in a number of cell proliferation and survival pathways. SphK is found to play a key role in ET-1 mediated myometrial contraction. This review highlights SphK as a prospective target with great potential to prevent preterm birth.
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spelling pubmed-36812862013-07-01 Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth Vyas, Vibhuti Ashby, Charles R. Reznik, Sandra E. Obstet Gynecol Int Review Article Preterm birth is defined as any delivery before 37 complete weeks of gestation. It is a universal challenge in the field of obstetrics owing to its high rate of mortality, long-term morbidity, associated human suffering and economic burden. In the United States, about 12.18% deliveries in 2009 were preterm, producing an exorbitant cost of $5.8 billion. Infection-associated premature rupture of membranes (PROM) accounts for 40% of extremely preterm births (<28 weeks of gestation). Major research efforts are directed towards improving the understanding of the pathophysiology of preterm birth and ways to prevent or at least postpone delivery. Endothelin-1 (ET-1) is a potent vasoconstrictor that plays a significant role in infection-triggered preterm birth. Its involvement in a number of pathological mechanisms and its elevation in preterm delivered amniotic fluid samples implicate it in preterm birth. Sphingosine kinase (SphK) is a ubiquitous enzyme responsible for the production of sphingosine-1-phosphate (S1P). S1P acts as second messenger in a number of cell proliferation and survival pathways. SphK is found to play a key role in ET-1 mediated myometrial contraction. This review highlights SphK as a prospective target with great potential to prevent preterm birth. Hindawi Publishing Corporation 2013 2013-05-26 /pmc/articles/PMC3681286/ /pubmed/23818902 http://dx.doi.org/10.1155/2013/302952 Text en Copyright © 2013 Vibhuti Vyas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vyas, Vibhuti
Ashby, Charles R.
Reznik, Sandra E.
Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth
title Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth
title_full Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth
title_fullStr Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth
title_full_unstemmed Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth
title_short Sphingosine Kinase: A Novel Putative Target for the Prevention of Infection-Triggered Preterm Birth
title_sort sphingosine kinase: a novel putative target for the prevention of infection-triggered preterm birth
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681286/
https://www.ncbi.nlm.nih.gov/pubmed/23818902
http://dx.doi.org/10.1155/2013/302952
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