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Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer
This paper is a systematic review of evidence-based studies of the effectiveness of Chinese herbal medicine (CHM) in the treatment of liver cancer. After a detailed analysis of the literature, five animal studies and four human clinical trials met the criteria for inclusion. Analysis revealed that r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681299/ https://www.ncbi.nlm.nih.gov/pubmed/23818930 http://dx.doi.org/10.1155/2013/656351 |
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author | Zheng, Zhan Cho, William Chi-Shing Xu, Ling Wang, Juyong Sze, Daniel Man-Yuen |
author_facet | Zheng, Zhan Cho, William Chi-Shing Xu, Ling Wang, Juyong Sze, Daniel Man-Yuen |
author_sort | Zheng, Zhan |
collection | PubMed |
description | This paper is a systematic review of evidence-based studies of the effectiveness of Chinese herbal medicine (CHM) in the treatment of liver cancer. After a detailed analysis of the literature, five animal studies and four human clinical trials met the criteria for inclusion. Analysis revealed that results of the clinical trials, whilst encouraging, need to be interpreted with caution as problems with study designs may lead to apparent benefits being attributable to various forms of bias. However, as each of the CHM agents used in these studies appeared to be potentially beneficial, further well-designed and controlled randomized clinical trials are warranted. The second part of this review focused on the lessons learned from the relationships between Traditional Chinese Medicine (TCM) theory, TCM Syndrome Differentiation, and modern scientific understanding of mechanisms of action of CHM agents. The understanding of TCM Syndrome Differentiation may allow identification of different patterns of disharmony and may provide important guidance to the prescription of CHM. Furthermore, quality control using both biological and chemical fingerprinting of CHM is important to ensure batch-to-batch consistency to deliver sustained therapeutic benefit. Also, careful assessment of herb-drug interactions is paramount for safety and integrative use of western chemotherapeutic and CHM agents. |
format | Online Article Text |
id | pubmed-3681299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36812992013-07-01 Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer Zheng, Zhan Cho, William Chi-Shing Xu, Ling Wang, Juyong Sze, Daniel Man-Yuen Evid Based Complement Alternat Med Review Article This paper is a systematic review of evidence-based studies of the effectiveness of Chinese herbal medicine (CHM) in the treatment of liver cancer. After a detailed analysis of the literature, five animal studies and four human clinical trials met the criteria for inclusion. Analysis revealed that results of the clinical trials, whilst encouraging, need to be interpreted with caution as problems with study designs may lead to apparent benefits being attributable to various forms of bias. However, as each of the CHM agents used in these studies appeared to be potentially beneficial, further well-designed and controlled randomized clinical trials are warranted. The second part of this review focused on the lessons learned from the relationships between Traditional Chinese Medicine (TCM) theory, TCM Syndrome Differentiation, and modern scientific understanding of mechanisms of action of CHM agents. The understanding of TCM Syndrome Differentiation may allow identification of different patterns of disharmony and may provide important guidance to the prescription of CHM. Furthermore, quality control using both biological and chemical fingerprinting of CHM is important to ensure batch-to-batch consistency to deliver sustained therapeutic benefit. Also, careful assessment of herb-drug interactions is paramount for safety and integrative use of western chemotherapeutic and CHM agents. Hindawi Publishing Corporation 2013 2013-05-29 /pmc/articles/PMC3681299/ /pubmed/23818930 http://dx.doi.org/10.1155/2013/656351 Text en Copyright © 2013 Zhan Zheng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zheng, Zhan Cho, William Chi-Shing Xu, Ling Wang, Juyong Sze, Daniel Man-Yuen Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer |
title | Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer |
title_full | Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer |
title_fullStr | Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer |
title_full_unstemmed | Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer |
title_short | Lessons Learnt from Evidence-Based Approach of Using Chinese Herbal Medicines in Liver Cancer |
title_sort | lessons learnt from evidence-based approach of using chinese herbal medicines in liver cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681299/ https://www.ncbi.nlm.nih.gov/pubmed/23818930 http://dx.doi.org/10.1155/2013/656351 |
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