Cargando…

Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease

In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of...

Descripción completa

Detalles Bibliográficos
Autores principales: Cordiali-Fei, Paola, Mussi, Anna, D'Agosto, Giovanna, Trento, Elisabetta, Bordignon, Valentina, Trincone, Silvana, Vento, Antonella, Sperduti, Isabella, Cristaudo, Antonio, Ensoli, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681301/
https://www.ncbi.nlm.nih.gov/pubmed/23818915
http://dx.doi.org/10.1155/2013/390563
_version_ 1782273237798879232
author Cordiali-Fei, Paola
Mussi, Anna
D'Agosto, Giovanna
Trento, Elisabetta
Bordignon, Valentina
Trincone, Silvana
Vento, Antonella
Sperduti, Isabella
Cristaudo, Antonio
Ensoli, Fabrizio
author_facet Cordiali-Fei, Paola
Mussi, Anna
D'Agosto, Giovanna
Trento, Elisabetta
Bordignon, Valentina
Trincone, Silvana
Vento, Antonella
Sperduti, Isabella
Cristaudo, Antonio
Ensoli, Fabrizio
author_sort Cordiali-Fei, Paola
collection PubMed
description In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, and in patients presenting with clinical signs and symptoms of UCTD. A large panel of serum antibodies directed towards nuclear, nucleolar, and cytoplasmic antigens, including well-recognized molecules as well as less frequently tested antigens, was assessed in order to determine whether different antibody profiles might be associated with distinct clinical settings. Beside the well-recognized association between lcSSc and anti-centromeric or dcSSC and anti-topoisomerase-I antibodies, we found a significative association between dcSSc and anti-SRP or anti-PL-7/12 antibodies. In addition, two distinct groups emerged on the basis of anti-RNP or anti-PM-Scl 75/100 antibody production among UCTD patients. The levels of T reg cells were significantly lower in patients with SSc as compared to patients with UCTD or to healthy controls; in patients with lcSSc, T reg cells were inversely correlated to disease duration, suggesting that their levels may represent a marker of disease progression.
format Online
Article
Text
id pubmed-3681301
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36813012013-07-01 Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease Cordiali-Fei, Paola Mussi, Anna D'Agosto, Giovanna Trento, Elisabetta Bordignon, Valentina Trincone, Silvana Vento, Antonella Sperduti, Isabella Cristaudo, Antonio Ensoli, Fabrizio Clin Dev Immunol Clinical Study In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, and in patients presenting with clinical signs and symptoms of UCTD. A large panel of serum antibodies directed towards nuclear, nucleolar, and cytoplasmic antigens, including well-recognized molecules as well as less frequently tested antigens, was assessed in order to determine whether different antibody profiles might be associated with distinct clinical settings. Beside the well-recognized association between lcSSc and anti-centromeric or dcSSC and anti-topoisomerase-I antibodies, we found a significative association between dcSSc and anti-SRP or anti-PL-7/12 antibodies. In addition, two distinct groups emerged on the basis of anti-RNP or anti-PM-Scl 75/100 antibody production among UCTD patients. The levels of T reg cells were significantly lower in patients with SSc as compared to patients with UCTD or to healthy controls; in patients with lcSSc, T reg cells were inversely correlated to disease duration, suggesting that their levels may represent a marker of disease progression. Hindawi Publishing Corporation 2013 2013-05-29 /pmc/articles/PMC3681301/ /pubmed/23818915 http://dx.doi.org/10.1155/2013/390563 Text en Copyright © 2013 Paola Cordiali-Fei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Cordiali-Fei, Paola
Mussi, Anna
D'Agosto, Giovanna
Trento, Elisabetta
Bordignon, Valentina
Trincone, Silvana
Vento, Antonella
Sperduti, Isabella
Cristaudo, Antonio
Ensoli, Fabrizio
Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease
title Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease
title_full Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease
title_fullStr Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease
title_full_unstemmed Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease
title_short Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease
title_sort assessment of t regulatory cells and expanded profiling of autoantibodies may offer novel biomarkers for the clinical management of systemic sclerosis and undifferentiated connective tissue disease
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681301/
https://www.ncbi.nlm.nih.gov/pubmed/23818915
http://dx.doi.org/10.1155/2013/390563
work_keys_str_mv AT cordialifeipaola assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT mussianna assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT dagostogiovanna assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT trentoelisabetta assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT bordignonvalentina assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT trinconesilvana assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT ventoantonella assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT sperdutiisabella assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT cristaudoantonio assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease
AT ensolifabrizio assessmentoftregulatorycellsandexpandedprofilingofautoantibodiesmayoffernovelbiomarkersfortheclinicalmanagementofsystemicsclerosisandundifferentiatedconnectivetissuedisease