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Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study

INTRODUCTION: Many supposed low-risk intensive care unit (ICU) admissions develop acute organ failure (AOF). Identifying patients at high risk of developing AOF and targeting them with preventative strategies may be effective. Our study question was: in a population of ICU patients receiving positiv...

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Autores principales: Terblanche, Marius, Kruger, Peter, Gangi, Stefania di, Gearay, Sadiq, Gilfeather, Lynn, Ferguson, Niall D, Pearse, Rupert, Beale, Richard, Rhodes, Andrew, Brett, Stephen J, McAuley, Daniel F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681390/
https://www.ncbi.nlm.nih.gov/pubmed/22512834
http://dx.doi.org/10.1186/cc11306
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author Terblanche, Marius
Kruger, Peter
Gangi, Stefania di
Gearay, Sadiq
Gilfeather, Lynn
Ferguson, Niall D
Pearse, Rupert
Beale, Richard
Rhodes, Andrew
Brett, Stephen J
McAuley, Daniel F
author_facet Terblanche, Marius
Kruger, Peter
Gangi, Stefania di
Gearay, Sadiq
Gilfeather, Lynn
Ferguson, Niall D
Pearse, Rupert
Beale, Richard
Rhodes, Andrew
Brett, Stephen J
McAuley, Daniel F
author_sort Terblanche, Marius
collection PubMed
description INTRODUCTION: Many supposed low-risk intensive care unit (ICU) admissions develop acute organ failure (AOF). Identifying patients at high risk of developing AOF and targeting them with preventative strategies may be effective. Our study question was: in a population of ICU patients receiving positive pressure respiratory support (invasive or non-invasive) in the absence of non-respiratory AOF, what is the 14-day incidence of, risk factors for and time to acute organ failure? METHODS: In an international prospective cohort study, patients receiving positive pressure respiratory support (invasive or non-invasive) in the absence of non-respiratory AOF were enrolled and followed for 14 days. The primary outcome measure was the incidence of any AOF (defined as SOFA 3 to 4) during follow-up. RESULTS: A total of 123 of 766 screened patients (16.1%) were enrolled. Data are reported for 121 patients. In total, 45 out of 121 patients (37.2%) developed AOF. Mortality rates were higher in those with AOF: 17.8% versus 4.0% OR 5.11, P = 0.019) for ICU mortality; and 28.9% versus 11.8% (OR 2.80, P = 0.019) for hospital mortality. Median ICU length of stay was also longer in those with AOF (11 versus 3.0 days; P < 0.0001). Hypoxemic respiratory failure (P = 0.001) and cardiovascular dysfunction (that is, SOFA 1 to 2; P = 0.03) were associated with AOF. The median time to first AOF was two days. CONCLUSIONS: Patients receiving positive (invasive or non-invasive) pressure respiratory support in the absence of non-respiratory AOF are commonly admitted to ICU; AOF is frequent in these patients. Organ failure developed within a short period after admission. Hypoxemic respiratory failure and cardiovascular dysfunction were strongly associated with AOF.
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spelling pubmed-36813902013-06-25 Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study Terblanche, Marius Kruger, Peter Gangi, Stefania di Gearay, Sadiq Gilfeather, Lynn Ferguson, Niall D Pearse, Rupert Beale, Richard Rhodes, Andrew Brett, Stephen J McAuley, Daniel F Crit Care Research INTRODUCTION: Many supposed low-risk intensive care unit (ICU) admissions develop acute organ failure (AOF). Identifying patients at high risk of developing AOF and targeting them with preventative strategies may be effective. Our study question was: in a population of ICU patients receiving positive pressure respiratory support (invasive or non-invasive) in the absence of non-respiratory AOF, what is the 14-day incidence of, risk factors for and time to acute organ failure? METHODS: In an international prospective cohort study, patients receiving positive pressure respiratory support (invasive or non-invasive) in the absence of non-respiratory AOF were enrolled and followed for 14 days. The primary outcome measure was the incidence of any AOF (defined as SOFA 3 to 4) during follow-up. RESULTS: A total of 123 of 766 screened patients (16.1%) were enrolled. Data are reported for 121 patients. In total, 45 out of 121 patients (37.2%) developed AOF. Mortality rates were higher in those with AOF: 17.8% versus 4.0% OR 5.11, P = 0.019) for ICU mortality; and 28.9% versus 11.8% (OR 2.80, P = 0.019) for hospital mortality. Median ICU length of stay was also longer in those with AOF (11 versus 3.0 days; P < 0.0001). Hypoxemic respiratory failure (P = 0.001) and cardiovascular dysfunction (that is, SOFA 1 to 2; P = 0.03) were associated with AOF. The median time to first AOF was two days. CONCLUSIONS: Patients receiving positive (invasive or non-invasive) pressure respiratory support in the absence of non-respiratory AOF are commonly admitted to ICU; AOF is frequent in these patients. Organ failure developed within a short period after admission. Hypoxemic respiratory failure and cardiovascular dysfunction were strongly associated with AOF. BioMed Central 2012 2012-04-18 /pmc/articles/PMC3681390/ /pubmed/22512834 http://dx.doi.org/10.1186/cc11306 Text en Copyright ©2012 Terblanche et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Terblanche, Marius
Kruger, Peter
Gangi, Stefania di
Gearay, Sadiq
Gilfeather, Lynn
Ferguson, Niall D
Pearse, Rupert
Beale, Richard
Rhodes, Andrew
Brett, Stephen J
McAuley, Daniel F
Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study
title Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study
title_full Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study
title_fullStr Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study
title_full_unstemmed Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study
title_short Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study
title_sort risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681390/
https://www.ncbi.nlm.nih.gov/pubmed/22512834
http://dx.doi.org/10.1186/cc11306
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