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Early neurovascular uncoupling in the brain during community acquired pneumonia
INTRODUCTION: Sepsis leads to microcirculatory dysfunction and therefore a disturbed neurovascular coupling in the brain. To investigate if the dysfunction is also present in less severe inflammatory diseases we studied the neurovascular coupling in patients suffering from community acquired pneumon...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681393/ https://www.ncbi.nlm.nih.gov/pubmed/22520083 http://dx.doi.org/10.1186/cc11310 |
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author | Rosengarten, Bernhard Krekel, Dennis Kuhnert, Stefan Schulz, Richard |
author_facet | Rosengarten, Bernhard Krekel, Dennis Kuhnert, Stefan Schulz, Richard |
author_sort | Rosengarten, Bernhard |
collection | PubMed |
description | INTRODUCTION: Sepsis leads to microcirculatory dysfunction and therefore a disturbed neurovascular coupling in the brain. To investigate if the dysfunction is also present in less severe inflammatory diseases we studied the neurovascular coupling in patients suffering from community acquired pneumonia. METHODS: Patients were investigated in the acute phase of pneumonia and after recovery. The neurovascular coupling was investigated with a simultaneous electroencephalogram (EEG)-Doppler technique applying a visual stimulation paradigm. Resting EEG frequencies, visual evoked potentials as well as resting and stimulated hemodynamic responses were obtained. Disease severity was characterized by laboratory and cognitive parameters as well as related scoring systems. Data were compared to a control group. RESULTS: Whereas visually evoked potentials (VEP) remained stable a significant slowing and therefore uncoupling of the hemodynamic responses were found in the acute phase of pneumonia (Rate time: control group: 3.6 ± 2.5 vs. acute pneumonia: 1.6 ± 2.4 s; P < 0.0005). In the initial investigation, patients who deteriorated showed a decreased hemodynamic response as compared with those who recovered (gain: recovered: 15% ± 4% vs. deteriorated: 9% ± 3%, P < 0.05; control: 14% ± 5%). After recovery the coupling normalized. CONCLUSIONS: Our study underlines the role of an early microcirculatory dysfunction in inflammatory syndromes that become evident in pre-septic conditions with a gradual decline according to disease severity. |
format | Online Article Text |
id | pubmed-3681393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36813932013-06-25 Early neurovascular uncoupling in the brain during community acquired pneumonia Rosengarten, Bernhard Krekel, Dennis Kuhnert, Stefan Schulz, Richard Crit Care Research INTRODUCTION: Sepsis leads to microcirculatory dysfunction and therefore a disturbed neurovascular coupling in the brain. To investigate if the dysfunction is also present in less severe inflammatory diseases we studied the neurovascular coupling in patients suffering from community acquired pneumonia. METHODS: Patients were investigated in the acute phase of pneumonia and after recovery. The neurovascular coupling was investigated with a simultaneous electroencephalogram (EEG)-Doppler technique applying a visual stimulation paradigm. Resting EEG frequencies, visual evoked potentials as well as resting and stimulated hemodynamic responses were obtained. Disease severity was characterized by laboratory and cognitive parameters as well as related scoring systems. Data were compared to a control group. RESULTS: Whereas visually evoked potentials (VEP) remained stable a significant slowing and therefore uncoupling of the hemodynamic responses were found in the acute phase of pneumonia (Rate time: control group: 3.6 ± 2.5 vs. acute pneumonia: 1.6 ± 2.4 s; P < 0.0005). In the initial investigation, patients who deteriorated showed a decreased hemodynamic response as compared with those who recovered (gain: recovered: 15% ± 4% vs. deteriorated: 9% ± 3%, P < 0.05; control: 14% ± 5%). After recovery the coupling normalized. CONCLUSIONS: Our study underlines the role of an early microcirculatory dysfunction in inflammatory syndromes that become evident in pre-septic conditions with a gradual decline according to disease severity. BioMed Central 2012 2012-04-20 /pmc/articles/PMC3681393/ /pubmed/22520083 http://dx.doi.org/10.1186/cc11310 Text en Copyright ©2012 Rosengarten et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Rosengarten, Bernhard Krekel, Dennis Kuhnert, Stefan Schulz, Richard Early neurovascular uncoupling in the brain during community acquired pneumonia |
title | Early neurovascular uncoupling in the brain during community acquired pneumonia |
title_full | Early neurovascular uncoupling in the brain during community acquired pneumonia |
title_fullStr | Early neurovascular uncoupling in the brain during community acquired pneumonia |
title_full_unstemmed | Early neurovascular uncoupling in the brain during community acquired pneumonia |
title_short | Early neurovascular uncoupling in the brain during community acquired pneumonia |
title_sort | early neurovascular uncoupling in the brain during community acquired pneumonia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681393/ https://www.ncbi.nlm.nih.gov/pubmed/22520083 http://dx.doi.org/10.1186/cc11310 |
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