Cargando…
Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma
OBJECTIVE: The goal of this study was to investigate the between cluster of differentiation 109 (CD109) expression and tumor diameter, invasion depth, tumor grade, presence of lymph-node metastasis, and overall survival in patients with vulvar squamous cell carcinoma, which is the most common type o...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681417/ https://www.ncbi.nlm.nih.gov/pubmed/23776335 http://dx.doi.org/10.2147/OTT.S41069 |
_version_ | 1782273261742063616 |
---|---|
author | Özbay, Pelin Özün Ekinci, Tekin Yiǧit, Seyran Yavuzcan, Ali Uysal, Selda Soylu, Ferit Cakalagaoglu, Fulya |
author_facet | Özbay, Pelin Özün Ekinci, Tekin Yiǧit, Seyran Yavuzcan, Ali Uysal, Selda Soylu, Ferit Cakalagaoglu, Fulya |
author_sort | Özbay, Pelin Özün |
collection | PubMed |
description | OBJECTIVE: The goal of this study was to investigate the between cluster of differentiation 109 (CD109) expression and tumor diameter, invasion depth, tumor grade, presence of lymph-node metastasis, and overall survival in patients with vulvar squamous cell carcinoma, which is the most common type of vulvar cancer. METHOD: Twenty-six patients who underwent an operation for vulvar cancer between 1999 and 2009 in our clinic were included in this study. Immunohistochemical staining was performed on formalin-fixed and paraffin-embedded tissue. RESULT: Tumor diameter was not found to be significantly associated with CD109 expression, intensity of cytoplasmic staining, or combined score (P = 0.325, P = 0.169, P = 0.352, respectively). Invasion depth and combined score were also not significantly correlated with CD109 expression (P = 0.324 and P = 0.174 respectively). There was a negative correlation between invasion depth and the intensity of cytoplasmic staining (P = 0.042). There was no significant correlation between tumor stage and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.574, P = 0.389, P = 0.605, respectively). A significant positive correlation was observed between tumor grade and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.003, P = 0.018, P = 0.008, respectively). No significant difference was found between the percentages of CD109 expression in patients with positive (48%) and negative (11%) lymph nodes (P = 0.058). The percentage of CD109 expression did not significantly differ in relation to overall survival (P = 0.483). CONCLUSION: Comprehensive and more extensive studies are needed to examine the relationship between CD109 expression and vulvar malignant lesions. |
format | Online Article Text |
id | pubmed-3681417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-36814172013-06-17 Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma Özbay, Pelin Özün Ekinci, Tekin Yiǧit, Seyran Yavuzcan, Ali Uysal, Selda Soylu, Ferit Cakalagaoglu, Fulya Onco Targets Ther Original Research OBJECTIVE: The goal of this study was to investigate the between cluster of differentiation 109 (CD109) expression and tumor diameter, invasion depth, tumor grade, presence of lymph-node metastasis, and overall survival in patients with vulvar squamous cell carcinoma, which is the most common type of vulvar cancer. METHOD: Twenty-six patients who underwent an operation for vulvar cancer between 1999 and 2009 in our clinic were included in this study. Immunohistochemical staining was performed on formalin-fixed and paraffin-embedded tissue. RESULT: Tumor diameter was not found to be significantly associated with CD109 expression, intensity of cytoplasmic staining, or combined score (P = 0.325, P = 0.169, P = 0.352, respectively). Invasion depth and combined score were also not significantly correlated with CD109 expression (P = 0.324 and P = 0.174 respectively). There was a negative correlation between invasion depth and the intensity of cytoplasmic staining (P = 0.042). There was no significant correlation between tumor stage and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.574, P = 0.389, P = 0.605, respectively). A significant positive correlation was observed between tumor grade and CD109 expression, the intensity of cytoplasmic staining, and the combined score (P = 0.003, P = 0.018, P = 0.008, respectively). No significant difference was found between the percentages of CD109 expression in patients with positive (48%) and negative (11%) lymph nodes (P = 0.058). The percentage of CD109 expression did not significantly differ in relation to overall survival (P = 0.483). CONCLUSION: Comprehensive and more extensive studies are needed to examine the relationship between CD109 expression and vulvar malignant lesions. Dove Medical Press 2013-06-07 /pmc/articles/PMC3681417/ /pubmed/23776335 http://dx.doi.org/10.2147/OTT.S41069 Text en © 2013 Özün Özbay et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Özbay, Pelin Özün Ekinci, Tekin Yiǧit, Seyran Yavuzcan, Ali Uysal, Selda Soylu, Ferit Cakalagaoglu, Fulya Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma |
title | Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma |
title_full | Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma |
title_fullStr | Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma |
title_full_unstemmed | Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma |
title_short | Investigation of prognostic significance of CD109 expression in women with vulvar squamous cell carcinoma |
title_sort | investigation of prognostic significance of cd109 expression in women with vulvar squamous cell carcinoma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681417/ https://www.ncbi.nlm.nih.gov/pubmed/23776335 http://dx.doi.org/10.2147/OTT.S41069 |
work_keys_str_mv | AT ozbaypelinozun investigationofprognosticsignificanceofcd109expressioninwomenwithvulvarsquamouscellcarcinoma AT ekincitekin investigationofprognosticsignificanceofcd109expressioninwomenwithvulvarsquamouscellcarcinoma AT yigitseyran investigationofprognosticsignificanceofcd109expressioninwomenwithvulvarsquamouscellcarcinoma AT yavuzcanali investigationofprognosticsignificanceofcd109expressioninwomenwithvulvarsquamouscellcarcinoma AT uysalselda investigationofprognosticsignificanceofcd109expressioninwomenwithvulvarsquamouscellcarcinoma AT soyluferit investigationofprognosticsignificanceofcd109expressioninwomenwithvulvarsquamouscellcarcinoma AT cakalagaoglufulya investigationofprognosticsignificanceofcd109expressioninwomenwithvulvarsquamouscellcarcinoma |