Cargando…

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio

Detalles Bibliográficos
Autores principales:	Alain, Tommy, Sonenberg, Nahum, Topisirovic, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2012
Materias:	Editorial
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681483/ https://www.ncbi.nlm.nih.gov/pubmed/23455427

Ejemplares similares

Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis
por: Zakaria, Chadi, et al.
Publicado: (2018)

Signalling to eIF4E in cancer
por: Siddiqui, Nadeem, et al.
Publicado: (2015)

Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1
por: Grosso, Stefano, et al.
Publicado: (2011)

The Distribution of eIF4E-Family Members across Insecta
por: Tettweiler, Gritta, et al.
Publicado: (2012)

eIF4E3 forms an active eIF4F complex during stresses (eIF4F(S)) targeting mTOR and re-programs the translatome
por: Weiss, Benjamin, et al.
Publicado: (2021)

The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior
por: Wiebe, Shane, et al.
Publicado: (2020)

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3
por: Tsukumo, Yoshinori, et al.
Publicado: (2016)

Nuclear Eukaryotic Initiation Factor 4e (Eif4e) Colocalizes with Splicing Factors in Speckles
por: Dostie, Josée, et al.
Publicado: (2000)

Metformin blocks MYC protein synthesis in colorectal cancer via mTOR‐4EBP‐eIF4E and MNK1‐eIF4G‐eIF4E signaling
por: Shen, Peng, et al.
Publicado: (2018)

4E-BP restrains eIF4E phosphorylation
por: Müller, David, et al.
Publicado: (2013)

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay
por: Ferraiuolo, Maria A., et al.
Publicado: (2005)

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer
por: Satheesha, Sampoorna, et al.
Publicado: (2011)

Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy
por: Romagnoli, Alice, et al.
Publicado: (2021)

The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase
por: Sun, Yingjie, et al.
Publicado: (2012)

Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer
por: Matsumoto, Masaru, et al.
Publicado: (2015)

Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
por: Dawson, Jennifer E., et al.
Publicado: (2020)

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
por: Wang, Jun, et al.
Publicado: (2017)

Dendritic eIF4E-binding Protein 1 (eIF4E-BP1) mRNA Is Upregulated by Neuronal Activation
por: Moon, Il Soo, et al.
Publicado: (2012)

C8ORF88: A Novel eIF4E-Binding Protein
por: Pugsley, Lauren, et al.
Publicado: (2023)

Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart
por: Santalla, Manuela, et al.
Publicado: (2022)

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3
por: Robichaud, Nathaniel, et al.
Publicado: (2014)

Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation
por: Mamane, Yaël, et al.
Publicado: (2007)

The Role of mTOR and eIF Signaling in Benign Endometrial Diseases
por: Driva, Tatiana S., et al.
Publicado: (2022)

Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference
por: Santhanam, Arti N., et al.
Publicado: (2009)

eIF4E is a central node of an RNA regulon that governs cellular proliferation
por: Culjkovic, Biljana, et al.
Publicado: (2006)

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts
por: Chaparro, Visnu, et al.
Publicado: (2020)

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation
por: Liberman, Noa, et al.
Publicado: (2015)

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy
por: Ramírez-Valle, Francisco, et al.
Publicado: (2008)

Light-regulated translational control of circadian behavior by eIF4E phosphorylation
por: Cao, Ruifeng, et al.
Publicado: (2015)

Correction: Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference
por: Santhanam, Arti N., et al.
Publicado: (2009)

Synergistic activation of eIF4A by eIF4B and eIF4G
por: Nielsen, Klaus H., et al.
Publicado: (2011)

Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia
por: Shi, Fangfang, et al.
Publicado: (2015)

The Androgen Receptor is a negative regulator of eIF4E Phosphorylation at S209: Implications for the use of mTOR inhibitors in advanced prostate cancer
por: D’Abronzo, Leandro S., et al.
Publicado: (2017)

4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia
por: Le Bacquer, Olivier, et al.
Publicado: (2019)

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
por: Livingstone, Mark, et al.
Publicado: (2012)

Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches
por: Martínez, Alba, et al.
Publicado: (2015)

Repair of Isoaspartate Formation Modulates the Interaction of Deamidated 4E-BP2 with mTORC1 in Brain
por: Bidinosti, Michael, et al.
Publicado: (2010)

eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis
por: Ruan, Hang, et al.
Publicado: (2020)

Requirement for the eIF4E Binding Proteins for the Synergistic Down-Regulation of Protein Synthesis by Hypertonic Conditions and mTOR Inhibition
por: Clemens, Michael J., et al.
Publicado: (2013)

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR
por: Culjkovic, Biljana, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_r368omisdbndk12p4jren8s2mp