PPARγ as a sensor of lipase activity and a target for the lipase inhibitor orlistat

A PPARγ fluorescence polarization (FP) assay was used to measure the release of fatty acid products from triglyceride emulsions during digestion with pancreatic and yeast lipases in a real-time, homogenous assay. Using the same FP assay we show the anti-obesity drug Orlistat is a PPARγ ligand with a...

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Detalles Bibliográficos
Autores principales: Martin, Harry, McGhie, Tony K, Bentley-Hewitt, Kerry, Christeller, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681555/
https://www.ncbi.nlm.nih.gov/pubmed/23566279
http://dx.doi.org/10.1186/1476-511X-12-48

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681555/
https://www.ncbi.nlm.nih.gov/pubmed/23566279
http://dx.doi.org/10.1186/1476-511X-12-48

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