Exploring Volatile General Anesthetic Binding to a Closed Membrane-Bound Bacterial Voltage-Gated Sodium Channel via Computation

Despite the clinical ubiquity of anesthesia, the molecular basis of anesthetic action is poorly understood. Amongst the many molecular targets proposed to contribute to anesthetic effects, the voltage gated sodium channels (VGSCs) should also be considered relevant, as they have been shown to be sen...

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Detalles Bibliográficos
Autores principales: Raju, S. G., Barber, Annika F., LeBard, David N., Klein, Michael L., Carnevale, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681623/
https://www.ncbi.nlm.nih.gov/pubmed/23785267
http://dx.doi.org/10.1371/journal.pcbi.1003090

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