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High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants

Genome-wide association studies (GWAS) have detected many disease associations. However, the reported variants tend to explain small fractions of risk, and there are doubts about issues such as the portability of findings over different ethnic groups or the relative roles of rare versus common varia...

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Detalles Bibliográficos
Autores principales: Marigorta, Urko M., Navarro, Arcadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681663/
https://www.ncbi.nlm.nih.gov/pubmed/23785302
http://dx.doi.org/10.1371/journal.pgen.1003566