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Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells
BACKGROUND: The cell surface receptors CD4 and CCR5 bind CCR5-tropic HIV Envelope (Env) glycoprotein during virus attachment. These same receptors have signaling activities related to normal immune cell functions. We also know that Env binds to CCR5 present at high levels on CD4-negative γδ T cells...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681682/ https://www.ncbi.nlm.nih.gov/pubmed/23742646 http://dx.doi.org/10.1186/1742-4690-10-60 |