Oxidative Stress and DNA Lesions: The Role of 8-Oxoguanine Lesions in Trypanosoma cruzi Cell Viability

The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characterist...

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Detalles Bibliográficos
Autores principales: Aguiar, Pedro H. N., Furtado, Carolina, Repolês, Bruno M., Ribeiro, Grazielle A., Mendes, Isabela C., Peloso, Eduardo F., Gadelha, Fernanda R., Macedo, Andrea M., Franco, Glória R., Pena, Sérgio D. J., Teixeira, Santuza M. R., Vieira, Leda Q., Guarneri, Alessandra A., Andrade, Luciana O., Machado, Carlos R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681716/
https://www.ncbi.nlm.nih.gov/pubmed/23785540
http://dx.doi.org/10.1371/journal.pntd.0002279

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