Multi-organ Abnormalities and mTORC1 Activation in Zebrafish Model of Multiple Acyl-CoA Dehydrogenase Deficiency

Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) is a severe mitochondrial disorder featuring multi-organ dysfunction. Mutations in either the ETFA, ETFB, and ETFDH genes can cause MADD but very little is known about disease specific mechanisms due to a paucity of animal models. We report a novel z...

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Detalles Bibliográficos
Autores principales: Kim, Seok-Hyung, Scott, Sarah A., Bennett, Michael J., Carson, Robert P., Fessel, Joshua, Brown, H. Alex, Ess, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681725/
https://www.ncbi.nlm.nih.gov/pubmed/23785301
http://dx.doi.org/10.1371/journal.pgen.1003563

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