Bacterial Cytolysin during Meningitis Disrupts the Regulation of Glutamate in the Brain, Leading to Synaptic Damage

Streptococcus pneumoniae (pneumococcal) meningitis is a common bacterial infection of the brain. The cholesterol-dependent cytolysin pneumolysin represents a key factor, determining the neuropathogenic potential of the pneumococci. Here, we demonstrate selective synaptic loss within the superficial...

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Detalles Bibliográficos
Autores principales: Wippel, Carolin, Maurer, Jana, Förtsch, Christina, Hupp, Sabrina, Bohl, Alexandra, Ma, Jiangtao, Mitchell, Timothy J., Bunkowski, Stephanie, Brück, Wolfgang, Nau, Roland, Iliev, Asparouh I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681734/
https://www.ncbi.nlm.nih.gov/pubmed/23785278
http://dx.doi.org/10.1371/journal.ppat.1003380

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