Induction and Role of Indoleamine 2,3 Dioxygenase in Mouse Models of Influenza A Virus Infection

Influenza infection stimulates protective host immune responses but paradoxically enhances lung indoleamine 2,3 dioxygenase (IDO) activity, an enzyme that suppresses helper/effector T cells and activates Foxp3-lineage regulatory CD4 T cells (Tregs). Influenza A/PR/8/34 (PR8) infection stimulated rap...

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Detalles Bibliográficos
Autores principales: Huang, Lei, Li, Lingqian, Klonowski, Kim D., Tompkins, S. Mark, Tripp, Ralph A., Mellor, Andrew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681773/
https://www.ncbi.nlm.nih.gov/pubmed/23785507
http://dx.doi.org/10.1371/journal.pone.0066546

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