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Thrombin Has Biphasic Effects on the Nitric Oxide-cGMP Pathway in Endothelial Cells and Contributes to Experimental Pulmonary Hypertension

BACKGROUND: A potential role for coagulation factors in pulmonary arterial hypertension has been recently described, but the mechanism of action is currently not known. Here, we investigated the interactions between thrombin and the nitric oxide-cGMP pathway in pulmonary endothelial cells and experi...

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Detalles Bibliográficos
Autores principales:	Nickel, Katrin F., Laux, Volker, Heumann, Rolf, von Degenfeld, Georges
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681801/ https://www.ncbi.nlm.nih.gov/pubmed/23785394 http://dx.doi.org/10.1371/journal.pone.0063504

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