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Calpain Inhibition Promotes the Rescue of F(508)del-CFTR in PBMC from Cystic Fibrosis Patients

A basal calpain activity promotes the limited proteolysis of wild type (WT) cystic fibrosis conductance regulator (CFTR), inducing the internalization of the split channel. This process contributes to the regulation in the level of the active CFTR at the plasma membranes. In peripheral blood mononuc...

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Detalles Bibliográficos
Autores principales:	Averna, Monica, Pedrazzi, Marco, Minicucci, Laura, De Tullio, Roberta, Cresta, Federico, Salamino, Franca, Pontremoli, Sandro, Melloni, Edon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681946/ https://www.ncbi.nlm.nih.gov/pubmed/23785472 http://dx.doi.org/10.1371/journal.pone.0066089

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