Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

Trichothiodystrophy (TTD) is a rare, autosomal recessive nucleotide excision repair (NER) disorder caused by mutations in components of the dual functional NER/basal transcription factor TFIIH. TTD mice, carrying a patient-based point mutation in the Xpd gene, strikingly resemble many features of th...

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Detalles Bibliográficos
Autores principales: Diderich, Karin E. M., Nicolaije, Claudia, Priemel, Matthias, Waarsing, Jan H., Day, Judd S., Brandt, Renata M. C., Schilling, Arndt F., Botter, Sander M., Weinans, Harrie, van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H. J., van Leeuwen, Johannes P. T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682057/
https://www.ncbi.nlm.nih.gov/pubmed/21814739
http://dx.doi.org/10.1007/s11357-011-9291-8

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