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Altered APP Carboxyl-Terminal Processing Under Ferrous Iron Treatment in PC12 Cells
Amyloid-β peptide (Aβ), generated by proteolytic cleavage of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). The key step in the generation of Aβ is cleavage of APP by beta-site APP-cleaving enzyme 1 (BACE1). Levels of BACE1 are increas...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Korean Physiological Society and The Korean Society of Pharmacology
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682078/ https://www.ncbi.nlm.nih.gov/pubmed/23776394 http://dx.doi.org/10.4196/kjpp.2013.17.3.189 |