Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()()

Both Gaucher disease patients and heterozygous glucocerebrosidase mutation carriers are at increased risk of Parkinson's disease. Retinal thinning has been reported in early Parkinson's disease. Here we used optical coherence tomography to demonstrate thinning of the retinal ganglion cell...

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Detalles Bibliográficos
Autores principales: McNeill, Alisdair, Roberti, Gloria, Lascaratos, Gerassimos, Hughes, Derralynn, Mehta, Atul, Garway-Heath, David F., Schapira, Anthony H.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2013
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682181/
https://www.ncbi.nlm.nih.gov/pubmed/23639447
http://dx.doi.org/10.1016/j.ymgme.2013.04.001
Descripción
Sumario:Both Gaucher disease patients and heterozygous glucocerebrosidase mutation carriers are at increased risk of Parkinson's disease. Retinal thinning has been reported in early Parkinson's disease. Here we used optical coherence tomography to demonstrate thinning of the retinal ganglion cell layer in Gaucher disease patients and carriers who manifest clinical markers of potential early neurodegeneration. Optical coherence tomography may help identify Gaucher disease patients and carriers at increased risk of developing Parkinson's disease.

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