Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()()

Both Gaucher disease patients and heterozygous glucocerebrosidase mutation carriers are at increased risk of Parkinson's disease. Retinal thinning has been reported in early Parkinson's disease. Here we used optical coherence tomography to demonstrate thinning of the retinal ganglion cell...

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Autores principales: McNeill, Alisdair, Roberti, Gloria, Lascaratos, Gerassimos, Hughes, Derralynn, Mehta, Atul, Garway-Heath, David F., Schapira, Anthony H.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2013
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682181/
https://www.ncbi.nlm.nih.gov/pubmed/23639447
http://dx.doi.org/10.1016/j.ymgme.2013.04.001
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author McNeill, Alisdair
Roberti, Gloria
Lascaratos, Gerassimos
Hughes, Derralynn
Mehta, Atul
Garway-Heath, David F.
Schapira, Anthony H.V.
author_facet McNeill, Alisdair
Roberti, Gloria
Lascaratos, Gerassimos
Hughes, Derralynn
Mehta, Atul
Garway-Heath, David F.
Schapira, Anthony H.V.
author_sort McNeill, Alisdair
collection PubMed
description Both Gaucher disease patients and heterozygous glucocerebrosidase mutation carriers are at increased risk of Parkinson's disease. Retinal thinning has been reported in early Parkinson's disease. Here we used optical coherence tomography to demonstrate thinning of the retinal ganglion cell layer in Gaucher disease patients and carriers who manifest clinical markers of potential early neurodegeneration. Optical coherence tomography may help identify Gaucher disease patients and carriers at increased risk of developing Parkinson's disease.
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spelling pubmed-36821812013-06-19 Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()() McNeill, Alisdair Roberti, Gloria Lascaratos, Gerassimos Hughes, Derralynn Mehta, Atul Garway-Heath, David F. Schapira, Anthony H.V. Mol Genet Metab Brief Communication Both Gaucher disease patients and heterozygous glucocerebrosidase mutation carriers are at increased risk of Parkinson's disease. Retinal thinning has been reported in early Parkinson's disease. Here we used optical coherence tomography to demonstrate thinning of the retinal ganglion cell layer in Gaucher disease patients and carriers who manifest clinical markers of potential early neurodegeneration. Optical coherence tomography may help identify Gaucher disease patients and carriers at increased risk of developing Parkinson's disease. Academic Press 2013-06 /pmc/articles/PMC3682181/ /pubmed/23639447 http://dx.doi.org/10.1016/j.ymgme.2013.04.001 Text en © 2013 The Authors https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Brief Communication
McNeill, Alisdair
Roberti, Gloria
Lascaratos, Gerassimos
Hughes, Derralynn
Mehta, Atul
Garway-Heath, David F.
Schapira, Anthony H.V.
Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()()
title Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()()
title_full Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()()
title_fullStr Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()()
title_full_unstemmed Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()()
title_short Retinal thinning in Gaucher disease patients and carriers: Results of a pilot study()()
title_sort retinal thinning in gaucher disease patients and carriers: results of a pilot study()()
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682181/
https://www.ncbi.nlm.nih.gov/pubmed/23639447
http://dx.doi.org/10.1016/j.ymgme.2013.04.001
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