A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?

New therapeutic approaches are sorely needed for acute lung injury. Neutrophil recruitment is a pathological hallmark of this syndrome, and is mainly regulated by CXC chemokine receptor 2 and its ligand CXC ligand 1. Rossaint and colleagues have described a new mechanism for regulation of this axis...

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Detalles Bibliográficos
Autores principales: Zasłona, Zbigniew, Peters-Golden, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682262/
https://www.ncbi.nlm.nih.gov/pubmed/23102473
http://dx.doi.org/10.1186/cc11519
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author Zasłona, Zbigniew
Peters-Golden, Marc
author_facet Zasłona, Zbigniew
Peters-Golden, Marc
author_sort Zasłona, Zbigniew
collection PubMed
description New therapeutic approaches are sorely needed for acute lung injury. Neutrophil recruitment is a pathological hallmark of this syndrome, and is mainly regulated by CXC chemokine receptor 2 and its ligand CXC ligand 1. Rossaint and colleagues have described a new mechanism for regulation of this axis by 12/15-lipoxygenase products. This work opens the door for new therapeutic approaches and highlights the crucial interplay between lipid mediators and chemokines, a time-honored but often-ignored concept.
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spelling pubmed-36822622013-10-25 A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised? Zasłona, Zbigniew Peters-Golden, Marc Crit Care Commentary New therapeutic approaches are sorely needed for acute lung injury. Neutrophil recruitment is a pathological hallmark of this syndrome, and is mainly regulated by CXC chemokine receptor 2 and its ligand CXC ligand 1. Rossaint and colleagues have described a new mechanism for regulation of this axis by 12/15-lipoxygenase products. This work opens the door for new therapeutic approaches and highlights the crucial interplay between lipid mediators and chemokines, a time-honored but often-ignored concept. BioMed Central 2012 2012-10-25 /pmc/articles/PMC3682262/ /pubmed/23102473 http://dx.doi.org/10.1186/cc11519 Text en Copyright ©2012 BioMed Central Ltd
spellingShingle Commentary
Zasłona, Zbigniew
Peters-Golden, Marc
A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
title A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
title_full A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
title_fullStr A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
title_full_unstemmed A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
title_short A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
title_sort lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682262/
https://www.ncbi.nlm.nih.gov/pubmed/23102473
http://dx.doi.org/10.1186/cc11519
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