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Recent Progress in Mouse Models for Tumor Suppressor Genes and its Implications in Human Cancer
Gain-of-function mutations in oncogenes and loss-of-function mutations in tumor suppressor genes (TSG) lead to cancer. In most human cancers, these mutations occur in somatic tissues. However, hereditary forms of cancer exist for which individuals are heterozygous for a germline mutation in a TSG lo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Libertas Academica
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682694/ https://www.ncbi.nlm.nih.gov/pubmed/23843721 http://dx.doi.org/10.4137/CMO.S10358 |