Sodium vanadate combined with l-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy

BACKGROUND: Proximal spinal muscular atrophy (SMA), a neurodegenerative disorder that causes infant mortality, has no effective treatment. Sodium vanadate has shown potential for the treatment of SMA; however, vanadate-induced toxicity in vivo remains an obstacle for its clinical application. We eva...

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Detalles Bibliográficos
Autores principales: Liu, Huei-Chun, Ting, Chen-Hung, Wen, Hsin-Lan, Tsai, Li-Kai, Hsieh-Li, Hsiu-Mei, Li, Hung, Lin-Chao, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682891/
https://www.ncbi.nlm.nih.gov/pubmed/23409868
http://dx.doi.org/10.1186/1741-7015-11-38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682891/
https://www.ncbi.nlm.nih.gov/pubmed/23409868
http://dx.doi.org/10.1186/1741-7015-11-38

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